药物性牙龈增生发病机制的研究进展

Progress in research on the pathogenesis of drug-induced gingival overgrowth

药物性牙龈增生是指服用抗癫痫药、钙通道阻滞剂和免疫抑制剂等某些特定药物引起的牙龈增生和体积增大,具有共同的病理组织学特点,其发病机制目前仍无定论。下面就药物性牙龈增生在胶原的合成与降解失衡、上皮细胞的增殖和程序性细胞死亡以及上皮下炎症浸润机制上取得的研究进展作一综述。

Drug-induced gingival overgrowth （DGO） is the gingival hyperplasia and volume enlargement, a side effect associated with 3 types of drugs： anticonvulsants, calcium channel blockers and immunosuppressive agents. It is characterized by some common pathological features. However, the mechanisms of these disorders have not been elucidated. This review focuses on the progress in research on the pathogenesis of DGO at 3 aspects： disruption of homeostasis of collagen synthesis and degradation, imbalance of proliferation and apoptosis of epithelial cell and subepidermal inflammation.