纳洛酮联合亚低温综合治疗原发性脑干损伤的临床分析

Clinical analysis of comprehensive treatment of Naloxone combined with mild hypothermia on primary brain stem injury

目的探讨纳洛酮与亚低温联合治疗原发性脑干损伤的临床疗效。方法将100例原发性脑干损伤患者随机分为治疗组和对照组各50例,其中对照组仅给予常规治疗,治疗组除常规治疗外,还加用纳洛酮与亚低温联合治疗,比较2组患者疗效。结果治疗组治愈率和总有效率均高于对照组(P<0.01),病死率则低于对照组(P<0.01);清醒时间明显短于对照组(P<0.01),致残率也明显比对照组低(P<0.01)。结论应用亚低温与盐酸纳洛酮联合治疗,疗效肯定且无明显不良反应,可使该病的病死率明显降低,缩短昏迷时间,减少残存率。

Objective To explore the clinical effect of Naloxone combined with mild hypothermia in the treatment of primary brain stem injury. Methods One hundred patients with primary brain stem injury were divided into therapeutic group and control group, 50 patients in each group. Patients in control group were given general therapy, but therapeutic group were treated with Naloxone combined with mild hypothermia based on general therapy. Then the effects in the two groups were compared. Results The curative ratio and total effective rate in therapeutic group were all higher than that in control group（P〈0.01）, but the mortality was lower（P〈0. 01） ;Lucid interval in therapeutic group was obviously less than that in control group（P〈0.01）, disabling rate in therapeutic group was obviously lower than that in control group（P〈0. 01）. Conclusion Naloxone combined with mild hypothermia are positive and no strong side-effect, it can reduce the mortality obviously ,shorten the coma time and reduce the disabling rate.