钙离子拮抗剂在高血压性脑出血治疗中的应用

Effect of calcium-channel blocker on hypertensive intracerebral hemorrhage

目的观察钙离子拮抗剂尼莫地平对高血压脑出血的临床作用。方法对84例高血压脑出血患者分治疗组和照组各42例,治疗组术后6h开始泵点尼莫地平,持续14d;对照组除不用尼莫地平外,其他同治疗组。对2组患者进行治疗前后功能评分并观察治疗前后神经功能、颅内血肿大小及周围水肿的变化。结果尼莫地平治疗组神经功能恢复明显,血肿及周围水肿面积较对照组显著减小(P<0.05)。结论尼莫地平能促进水肿和血肿吸收,抑制脑水肿形成,从而促进神经功能的恢复。

Objective To observe the clinical effect of calcium-channel blocker nimodipine in the treatment of hypertensive cerebral hemorrhage （HCH）. Methods Total 84 patients with HCH were randomly divided into treatment group and control group,42 cases of each group. Nimodipine was pumped continuously into the patients in treatment group 6 hours after operation for 14 days. The treatment of control group was similar to treatment group except nimodipine. The absorption of hemorrhage and edema were observed and compared between the two groups by blind trial to evaluate the neurological function. Results The recovery of neurological function of treatment group was obvious, hemorrhage and edema was significantly diminished（P〈0. 05）. Conclusion Nimodipine can benefit the absorption of hemorrhage and edema,and is helpful to improving neurological functions.