非洛地平缓释片治疗原发性高血压的谷峰比值与平滑指数研究

Study of the T/P ratio and smoothness index of Felodipine sustained-release tablet in the treatment of essential hypertension

目的探讨非洛地平缓释片治疗轻中度原发性高血压患者的谷峰比值和平滑指数。方法对28例轻中度高血压患者,口服非洛地平缓释片5mg,1次/d,疗程8周,于治疗前后进行24h动态血压监测并计算谷峰比值和平滑指数。结果治疗8周后,24h收缩压和舒张压,白昼收缩压和舒张压,夜间收缩压和舒张压与治疗前比较均有显著性差异(P<0.01),T/P为收缩压69%,舒张压70%。平滑指数为收缩压(1.09±0.57),舒张压(0.94±0.51)。结论非洛地平缓释片有较高的T/P比值及良好的平滑指数。

Objective To observe the T/P ratio and smoothness index of Felodipine sustained-release tablet in the treatment of patients with light or moderate essential hypertension. Methods Twenty-eight patients with light or moderate hypertension were taken orally Felodipine sustained-release tablet 5mg, once a day, treatment period was 8 weeks, 24 hours ambulatory blood pressure monitoring after/before treatment were taken and the T/P radio and smoothness index were counted . Results Eight weeks after treatment, compared with before treatment, 24 hours systolic blood pressure and 24 hours diastolic blood pressure, night systolic blood pressure and diastolic blood pressure had very significantly differences （P〈0. 01） ,T/P was systolic blood pressure 69%, diastolic 70%, smoothness index was systolic blood pressure （1.09 ± 0.57）, diastolic blood pressure was （0. 94± 0. 51）. Conclusion Felodipine sustained-release tablet has higher T/P ratio and good smoothness index.