Na^(188)ReO_4溶液活度测量的标准化研究

Study on the Standardization for the Radioactivity Measurement for Sodium Perrhenate ^(188)Re Solution

为了确保含188Re放射性药品用药安全有效,本工作对使用活度计测量Na188ReO4溶液活度的方法进行了标准化研究。采用3家实验室的4πβ液闪、4πβ-γ符合测量装置共4套独立测量系统对Na188ReO4溶液的活度进行了定值;再利用已知活度的标准源,对使用活度计测量Na188ReO4溶液活度的方法进行了标准化研究,确定了测量条件,并在3个地区的10台活度计上进行了活度测量比对试验。结果表明,利用CRC系列活度计对Na188ReO4溶液活度的测量结果与标准值的偏差均在±3%以内。因此,在确定的测量条件下,活度计适宜于测量Na188ReO4溶液的活度。

In order to determine the radioactivity of ^188Re radiopharmaceuticals accurately with dose calibrators , and ensure the safety and efficacy of the 188 Re radiopharmaceuticals, the standardization for the radioactivity measurement of sodium perrhenate ^188Re solution with dose calibrators were studied, in which 4n liquid scintillator and 4πβ-γ coincidence method were used to determine the values of radioactivity for the sodium perrhenate ^188Re Solution standard source with four experimental set-ups in three laboratories, then the dose calibrators were calibrated with the standard source, and the effect of the type of dose cali- brator, the container of the standard source, and the volume of the solution were studied systematically, at last the comparative test was carried out among 10 different dose calibra- tors in three cities. The results showed that the values of CRC series dose calibrators were all in coincidence within ±3%. In conclusion, having been calibrated by standardization, the CRC series dose calibrators can be used to accurately determine the radioactivity of sodium perrhenate ^188Re solution.