摘要
恶性肿瘤有着许多特征,但基本特征之一是细胞的异常分化。在肿瘤细胞向不成熟方向退行性发育的过程中,可出现原来组织或器官中的正常细胞所没有的新的分化特征或原有一些特征的丢失,这种分化不仅给肿瘤的诊断带来困难,同时也给肿瘤治疗造成了许多障碍。
出处
《医学新知》
CAS
2008年第4期229-231,共3页
New Medicine
参考文献17
-
1Tavassolia F,Devilee P. World Health Organization classification oftumours Pathology & genetics tumours of the breast and female genital organs[J]. Lyon: IARC Press, 2003:32-40.
-
2Eyden B, Pandit D, Banerjee S S. Malignant melanoma with neuroendocrine differentiation: clinical,histological, immunohistochemical and ultrastructural features of there cases[J].Histopathology, 2005,47: 402-409.
-
3向理科,米粲,罗子国,李圆圆.17例骨肉瘤伴神经内分泌分化[J].诊断病理学杂志,2000,7(3):175-177. 被引量:1
-
4Yao G Y, Zhou J L,Lai M D,et al.Neuroendocrine markers in adenocarcinoma:an investigation of 356 cases[J]. World J Gastroenterol,2003,9(4):860-861.
-
5Huang J, Yao J L, di Sant'Agnese P A, et al. Immunohistochemical characterization of neuroendocrine cells in prostate cancer[J].Prostate, 2006,66:1125-1135.
-
6Kamiya N,Akakura K, Suzuki H, et al. Pretreatment serum level ofneuron specific enolase (NSE) as a prognostic factor in metastatic prostate cancer patients treated with endocrine therapy[J]. European Urology, 2003,44(3): 309-314.
-
7Yang X D,Wang S, Meng H Y, et al.The prognosis value of human neuroendocrine clone on colorectal carcinoma [J]. Zhonghua Wai Ke Za Zhi,2005 , 43(11):706-709.
-
8Atasoy P, Bozdogan O,Ozturk S,et al.Bcl-2 expression and its correlation with neuroendocrine differentiation in colon carcinomas[J].Tumori,2004,90(2):233-238.
-
9何松,严桥,陈旭东,张建兵,陆晓云,潘宏佳,陈莉.胃癌细胞中神经内分泌分化与术后生存关系的研究[J].中国肿瘤临床,2007,34(22):1283-1286. 被引量:11
-
10Abdul M, Hoosein N. Relationship of the interleukin- 1 system with neuroendocrine and exocrine markers in human colon cancer cell lines[J].Cytokine,2002,18: 86-91.
二级参考文献12
-
1李惠珍,郑丽瑞.普通型胃癌伴神经内分泌分化的免疫组织化学观察[J].临床消化病杂志,2005,17(5):206-208. 被引量:5
-
2刘俊茹,魏守礼,高国栋,陈秀鉴,焦炳忠,王凤荣,刘庆银.胃癌中神经内分泌细胞的临床病理学意义[J].肿瘤防治研究,1996,23(6):347-349. 被引量:6
-
3那加,李竞贤,柳萍,沈雪群,李俊.骨与软组织小细胞恶性肿瘤22例临床病理分析[J].北京医科大学学报,1996,28(5):353-354. 被引量:8
-
4皋岚湘.伴神经内分泌分化的乳腺癌[J].诊断病理学杂志,1996,3(3):168-170. 被引量:7
-
5唐春莲,姚根有.胃癌伴神经内分泌分化的研究进展[J].国际病理科学与临床杂志,2007,27(2):130-132. 被引量:3
-
6Kamiya N, Akakura K, Suzuki H, et al. Pretreatrnent serum level of neuron specific enolase (NSE) as a prognostic factor in metastatic prostate cancer patients treated with endocrine therapy [J]. Eur Urol, 2003, 44(3): 309-314.
-
7Fujii A, Kamiakito T, Takayashiki N, et al. Neuroendocrine tissue-specific transcription factor, BETA2/NeuroD, in gastric carcinomas: a comparison with chromogranin A and synaptophysin expressions[]J. Pathol Res Pract, 2003, 199(8): 513-519.
-
8Kaltsas GA, Besser GM, Grossman AB. The diagnosis and medical management of advanced neuroendocrine tumors [J]. Endocr Rev, 2004, 25(3): 458-511.
-
9Eren F, Celikel C, Gulluoglu B. Neuroendocrine differentiation in gastric adenocarcinomas;correlation with tumor stage and expression of VEGF and p53[J]. Pathol Oncol Res, 2004, 10(1): 47-51.
-
10Naritomi K, Futami K, Arima S, et al. Malignant potential regarding mucin phenotypes and endocrine cell differentiation in gastric adenocarcinoma [J]. Anticancer Res, 2003, 23 (6a): 4411-4422
共引文献10
-
1陈旭东,何松,陆晓云,喻朝霞,戴瑜珍,周建云.甲状腺乳头状癌伴神经内分泌分化细胞的超微结构观察[J].南京医科大学学报(自然科学版),2008,28(8):1022-1026. 被引量:3
-
2王旺,波拉提.沙依提,马依尔.马合木提.甲状腺神经内分泌癌1例[J].中国普通外科杂志,2011,20(10):1036-1036.
-
3张高,霍丹,马玉芳,范军.残胃腺癌伴神经内分泌分化合并间质瘤1例[J].中国现代医药杂志,2011,13(12):95-95. 被引量:2
-
4郭思远,张忠涛,孟化.胃癌伴神经内分泌分化的研究现状[J].国际外科学杂志,2012,39(3):184-188. 被引量:2
-
5张婷婷,苏丹,王李杰,郗洪庆,毛志远,白莉.胃癌伴神经内分泌分化临床诊治及预后分析[J].军医进修学院学报,2012,33(12):1264-1267. 被引量:1
-
6于红梅,刘晓文,龙子雯,张力文,周梦龙,王亚农.胃癌伴神经内分泌分化的临床病理及预后分析[J].中国癌症杂志,2013,23(1):42-46. 被引量:13
-
7褚忠华,曾育杰.结直肠腺癌并神经内分泌分化研究进展[J].岭南现代临床外科,2013,13(6):471-474.
-
8邵明雯,孙婧,马兰,束永前,刘连科.具有神经内分泌性质食管癌的临床病理特点及生存分析[J].中华肿瘤防治杂志,2014,21(24):1980-1985. 被引量:11
-
9王健,张莹雯.益气养阴汤应用于早期胃癌经腔镜微创术后对患者免疫功能及预后的影响[J].世界中西医结合杂志,2017,12(4):570-572. 被引量:4
-
10于珊,吕敏之,罗荣奎,刘凤林,刘天舒.胃癌伴神经内分泌分化患者临床病理特征及根治术后生存分析[J].中华胃肠外科杂志,2021,24(5):426-432. 被引量:5
同被引文献20
-
1徐美林,刘岩,宋秀娴,杨霞.非小细胞肺癌伴神经内分泌分化的免疫组织化学研究[J].中国肿瘤临床,2005,32(3):165-167. 被引量:6
-
2付琼,姚根有,赵仲生.腺癌伴神经内分泌分化的研究进展[J].国际病理科学与临床杂志,2005,25(5):405-408. 被引量:2
-
3朱维娜,郭文君,李颖.肺腺癌神经内分泌分化的生物学特性[J].解剖科学进展,2006,12(1):50-51. 被引量:7
-
4梁超群,毛晓燕,刘晖,孟云霄,丛林.肺神经内分泌肿瘤的临床病理学分析[J].实用肿瘤学杂志,2006,20(2):125-126. 被引量:3
-
5范理宏,蔡映云.神经内分泌分化与非小细胞肺癌[J].肿瘤,2006,26(6):579-581. 被引量:6
-
6Graziano SL,Tatum AH,Newman NB,et al.The prognostic significance of neuroendocrine markers and carcinoembryonic andgen in patients with resected stage Ⅰ and Ⅱ non-small cell lung cancer[J].Gancer Res,1994,54(11):2908-2913.
-
7Monica V,Scagliotti GV,Geppi P,et al.Differential Thymidyhte Synthase Expression in Different Variants of Large-Cell Carinoma of the Lung[J].Glin Cancer Res,2009,15(24):7547-7552.
-
8Howe MG,GhapmanA,Kerr K,et al.Neuroendocrine differentiation in non-small cell lung cancer and its relation to prognosis and therapy[J].Histopathology,2005,46(2):195-201.
-
9Gonzalez-Aragoneses F,Moreno-Mata N,C,ebonero--Presmanes M,et al.Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung[J].Cancer,2007,110(8):1776-1781.
-
10Belshaw Z,Bacon N J,Foale R D,et al. Pancreatic mixed aci nar-endocrine carcinoma in a dog[J]. Veterinary and Comparative Oncology, 2005,3 (3) : 145-148.
引证文献3
-
1郭燕,孙蕾娜,栾焕玲,战忠利,孙保存.肺腺癌神经内分泌分化与其生物学行为及预后的相关性研究[J].中国肿瘤临床,2010,37(6):323-326. 被引量:3
-
2常玲玲,佘锐萍,李丰昌,岳卓,郭志胜,肖鹏,朱金凤.犬胰腺腺泡细胞癌伴发神经内分泌细胞分化病例的病理学观察[J].中国兽医杂志,2011,47(4):65-66.
-
3赵成帅,王梅.阿帕替尼治疗晚期胃癌一例报告及文献复习[J].中国肿瘤生物治疗杂志,2017,24(9):1037-1040. 被引量:1
二级引证文献4
-
1黄宇筠,袁润强,陈应智,袁小玲,缪卓峰,庄楚璇.伴神经内分泌分化肺腺癌血清癌胚抗原水平的分析[J].分子诊断与治疗杂志,2015,7(4):261-265. 被引量:8
-
2黎滨茹,姜又红.肺腺癌神经内分泌分化及其临床病理学的相关性[J].中国继续医学教育,2016,8(8):41-43.
-
3梁雪锋.肺腺癌伴神经内分泌分化的临床病理特征分析[J].中国乡村医药,2016,23(6):57-58.
-
4李宗宪,李志华,刘洋.阿帕替尼联合化疗治疗晚期胃癌患者的效果及对血管内皮生长因子受体2的影响[J].国际医药卫生导报,2019,25(9):1423-1427. 被引量:7
-
1陈竺.人类基因组和白血病的分化、凋亡诱导[J].科学中国人,1997(10):19-23.
-
2魏虎来,吴明德.白血病细胞分化诱导的形态学分析[J].甘肃医药,1992,11(6):321-324.
-
3董作仁,潘崚,徐世荣,张瑞欣,顾素琴,姚尔固.以全反式维甲酸为主的联合分化诱导方案治疗28例急性早幼粒细胞白血病疗效分析[J].山西白血病,1992,1(1):45-46.
-
4刘春莲,邵志浩.全反式维甲酸治疗急性早幼粒细胞白血病19例报告[J].滨州医学院学报,1997,20(4):401-402.
-
5李秋平,封志纯.细胞因子与树突状细胞分化诱导[J].国外医学(肿瘤学分册),2004,31(10):742-744. 被引量:3
-
6景永奎,韩锐.癌细胞分化诱导模型系统[J].国外医学(肿瘤学分册),1991,18(4):224-226.
-
7孙关林,卢家祥.急性早幼粒细胞白血病的诱导分化疗法:44例疗效分析[J].中华血液学杂志,1989,10(3):119-121. 被引量:10
-
8陈惠黎,查锡良,艾兆伟,秦琐高,刘毅.人肝癌细胞诱导分化的体外研究[J].医学研究杂志,1994,28(10):19-20.
-
9李桂芝,刘丽红,卢恩英.凋亡抑制基因Survivin与乳腺癌致病的研究进展[J].家庭心理医生,2014,10(12):103-103.
-
10乐晓萍,张钦宪,杜鹏,丁一,金辉,吴景兰.不同分化程度胃癌组织中hMSH2 mRNA的表达[J].河南医科大学学报,2001,36(4):389-392.