沙美特罗合成工艺研究

Study on the Process for Synthesis of Salmeterol

以水杨酸甲酯为原料,通过酰化、溴化、氨基化、还原和烷基化五步合成了沙美特罗,与现有工艺相比,用溴化铜取代液溴,用硼氢化钠和氯化锂代替四氢铝锂,减少了环境污染,降低了成本。

Salmeterol was synthesized from methyl salicylate by the process of acylation, bromization, amination, reduction and alkylation. Compared with provious synthetic process of salmeterol, this method can decrease pollution and reduce cost in which bromine was replaced by cupric bromide and lithium aluminum hydride was replaced by sodium borohydride/lithium chloride.