刺梨多糖对衰老小鼠体内抗氧化能力的影响

ANTIOXIDANT EFFECT OF POLYSACCHARIDE FROM ROSA ROXBURGHII IN AGED MICE

目的探讨刺梨多糖(RRTP)对衰老小鼠体内抗氧化能力的影响。方法用D-半乳糖所致衰老小鼠作为实验对象,灌胃给予RRTP100,200,400mg/kg.d,47d后观察其对小鼠血浆、肝脏、脑组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、过氧化氢酶(CAT)含量的影响。结果衰老小鼠血浆、肝脏、脑组织匀浆中SOD、CAT含量均显著降低,MDA含量显著升高;200,400mg/kg·dRRTP可以提高衰老小鼠血浆、肝脏、脑组织中SOD、CAT含量,降低MDA含量,与模型组比较,差异有显著性。结论RRTP可以剂量依赖性地提高衰老小鼠体内抗氧化能力。

Objective To investigate the antioxidant effect of polysaccharide from Rosa roxburghii （RRTP） in aged mice. Method Aged mice caused by D-galactose were perfused with 100, 200 and 400 mg/kg.d RRTP for 47 d, the effect of RRTP on the content of superoxide dismutase （SOD）, malondialdehyde （MDA）, catalase （CAT） in plasma, liver and brain were observed. Results The activities of SOD and CAT in plasma, liver and brain in aged mice were lower and the content of MDA was higher than those in the control. while in the aged mice treated with RRTP 200 and 400 mg/kg.d, the activity of SOD and CAT were significantly increased and the content of MDA decreased. Conclusion RRTP has antioxidant effect in aged mice and showed dose-and-effect relationship.