西宁地区睡眠呼吸暂停患者血液流变学和C-反应蛋白的变化

Changes of Hemorheology and C-reactive Protein in Obstructive Sleep Apnea Syndrome Patients in Xining Area

目的:探讨西宁地区阻塞性睡眠呼吸暂停综合征(OSAS)患者血浆高敏C-反应蛋白(hsCRP)和血液流变学的改变。方法:选取在我院经多导睡眠图确诊且未经治疗的OSAS患者59例为OSAS组,30例多导睡眠图(PSG)检查正常者为对照组,分别测定两组患者hsCRP水平及纤维蛋白原和血浆黏度的水平。结果:OSAS组与对照组相比血浆hsCRP水平(P<0.01)、纤维蛋白原(P<0.01)和血浆黏度(P<0.01)的水平增高。纤维蛋白原(r=0.776,P=0.01)、血浆黏度(r=0.702,P<0.01)、hsCRP(r=0.652,P<0.05)与呼吸紊乱指数(AHI)之间有相关性。结论:OSAS患者hsCRP、纤维蛋白原和血浆黏度的水平升高,且与OSAS严重程度有关。这些改变是心脑血管病危险因子之一。

Objective.-To observe changes on hemorheology and level of High--sensitivity C--reactive protein （hsCRP） in obstructive sleep apnea syndrome （OSAS） patients in Xining area. Methods：59 patients, who had been identified to have OSAS by polysomnography （PSG） but free of treatment, were designed in the OSAS group and 30 non--OSAS as control group. Plasma viscosity, level of Fibrinogen and hsCRP were determined in two groups. Results： Plasma viscosity, level of Fibrinogen and hsCRP was increased in the OSAS group compared with that in control group, there was a greater difference （P〈 0. 01）. And they have a correlation with AHI. Conclusions： Plasma viscosity, level of Fibrinogen and hsCRP in OSAS patients was higher and correlation with AHI. The result suggests that changes of them are one of risk factors on cardiovascular disease.