缺血性脑损伤及修复过程中cpg15基因的表达调控的初步研究
被引量：1
摘要
cpg15（candidate plasticity-related gene 15）是一种在神经组织中特异表达的神经可塑性相关基因，它所编码的CPG15蛋白在神经功能的多个方面，包括：在神经发育和神经重塑过程中具有促进神经突起生长和突触成熟、防止神经细胞凋亡等重要作用。我们已有的研究表明，该基因的表达在缺血性脑损伤及修复中受到显著调控，提示基因表达水平的调控与其在缺血性脑损伤及修复中的功能有关。
同被引文献33
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1Fujino T, Lee WC, Nedivi E. Regulation of cpg15 by signaling pathways that mediate synaptic plasticity [ J ]. Mol Cell Neurosci, 2003, 24:538 -554.
-
2Nedivi E, Hevroni D, Naot D, et al. Numerous candidate plasticity- related genes revealed by differential cDNA cloning [ J ]. Nature, 1993, 363:718 -722.
-
3Sharma N, Marzo SJ, Jones K J, et al. Electrical stimulation and testosterone differentially enhance expression of regeneration-associ- ated genes[J]. Exp Neurol, 2010, 223:183 - 191.
-
4Nedivi E, Fieldust S, Theill LE, et al. A set of genes expressed in response to light in the adult cerebral cortex and regulated during development[ J]. Proe Natl Acad Sci USA, 1996, 93:2048 - 2053.
-
5Naeve GS, Ramakrishnan M, Kramer R, et al. Neuritin : a gene in- duced by neural activity and neurotrophins that promotes neurito- genesis I J ]. Proc Natl Acad Sei USA, 1997, 94:2648 - 2653.
-
6Nedivi E, Javaherian A, Cantallops I, et al. Developmental regula- tion of CPG15 expression in Xenopus[ J]. J Comp Neurol, 2001, 435:464 - 473.
-
7Nedivi E, Wu GY, Cline HT. Promotion of dendritic growth by CPG15, an activity-induced signaling molecule [ J ]. Science, 1998, 281:1863 - 1866.
-
8Fujino T, Wu Z, Lin WC, et al. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival[J].J Comp Neurol, 2008, 507 : 1831 - 1845.
-
9Putz U, Harwell C, Nedivi E. Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis [J].Nat Neurosci, 2005, 8:322 - 331.
-
10Kojima N, Shiojiri N, Sakai Y, et al. Expression of Neuritin during liver maturation and regeneration[ J]. FEBS Lett, 2005,579:4562 - 4566.
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-
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-
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-
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