原发性高血压患者红细胞胰岛素受体与胰岛素测定的临床意义

CLINICAL SIGNIFICANCE OF RED BLOOD CELL INSULIN RECEPTORS AND FASTING SERUM INSULIN MEASUREMENTS IN ESSENTIAL HYPERTENSIVE PATIENTS

本文对67例原发性高血压患者,采用Gambhir改良法测定红细胞胰岛素受体含量,用放射免疫分析法测定空腹血清胰岛素浓度的变化。我们发现,原发性高血压患者红细胞胰岛素受体数目较对照组显著减少(p<0.01);而空腹血清胰岛素浓度明显升高(p<0.01)。结果表明,原发性高血压存在的胰岛素抵抗,其发病的主要环节是红细胞胰岛素受体数目的减少;胰岛素浓度升高是胰岛素抵抗的代偿反应,常与胰岛素抵抗共存。

Improved G-ambhir's Method was used to measure the number of the RBC insulin receptors and RIA was used to measura the changes of the level of fasting serum insulin in 67 essential hypertensive patients. The patients showed a higher fasting serum insulin level (p<0.05) and a fewer RBC insulin receptors(p<0.01) than the controts. The findings indicateed that there was insulin resistence(IR) in essential hypertension, which could be caused by decrease of RBC insulin receptirs.The higher level of irisulin was the compensatory response to IR.