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坏死性小肠结肠炎早产儿血小板活化因子水平的研究 被引量：4

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摘要 目的研究早产儿坏死性小肠结肠炎（NEC）血中血小板活化因子（PAF）水平的变化，探讨PAF与NEC的关系。方法采用ELISA方法测定21例早产儿NEC血中PAF浓度，同时检测35例早产儿、15例健康足月儿血中R姬浓度进行对照。结果早产儿NEC时PAF浓度（56．1±14．6）ng／L显著高于早产儿血中R姬浓度（9．44±3．31）ng／L（P〈0．001），高于健康足月儿血中PAF浓度（44．1±12．0）ng／L（P〈0．05）。结论早产儿NEC时血中PAF浓度增高，说明PAF在病理情况下参与了NEC的发病。
作者 杨红 肖志辉 唐风英
机构地区 江苏省盐城市妇幼保健医院新生儿科 苏州儿童医院
出处 《中国小儿急救医学》 CAS 2008年第1期68-69,共2页 Chinese Pediatric Emergency Medicine
关键词 早产儿 坏死性小肠结肠炎 血小板活化因子
分类号 R722.6 [医药卫生—儿科]
  • 相关文献

参考文献12

  • 1金汉珍,黄德珉.实用新生儿学[M].第3版.北京:人民卫生出版社,2001:269.
  • 2Ewer AK. Role of platelet-actlvating factor in the pathophysiology of necrotizing enterocolitis [J]. Acta Paediatr Suppl, 2002, 91 (437):2-5.
  • 3Hsueh W, Caplan MS, Qu XW, et al. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts[J]. Pediatr Dev Pathol, 2003, 6(1) : 6-23.
  • 4Muguruma K, Gray PW, Tjoelker LW, et al. The central role of PAF in necrotizing enterocolitis development [ J ]. Adv Exp Med Biol, 1997, 407:379-382.
  • 5陈志娟,陈涵强,黄妙辉.新生儿坏死性小肠结肠炎发病机制研究进展[J].国外医学（儿科学分册）,2003,30(4):169-171. 被引量：4
  • 6张家骥 魏克伦 薛辛东.新生儿急救学[M].北京:人民卫生出版社,2000..
  • 7Zhang C, Hsueh W. PAF-induced bowel necrosis. Effects of vasodilators[J]. Dig Dis Sci, 1991, 36(5) : 634-640.
  • 8王淑玉,孟繁杭.血小板活化因子与新生儿疾病[J].新生儿科杂志,2001,16(1):40-42. 被引量：5
  • 9Furukawa M, Iee EL, Johnston JM. Platalet-activating factor induced ischemic bowel necrosis:the effect of Platelet-activating factor, acetythydrolase[J]. Pediatr Res, 1993, 34(2):237-241.
  • 10Lucas A, Cole TJ. Breast milk and neonatal necrotizing enterccolitis [J]. Lancet, 1990, 336(8730) :1519-1523.

二级参考文献53

  • 1[1]Koltai M, Hosford D, Guinot P, et al. Platelet activating Factor(PAF). A review of its effects, antagonistsand possible future clinical implications. Drugs. 1991,42:9-29
  • 2[2]Akisu M, Kultursay N, Coker L, et al. platelet-activating factor levels in newborn infants with and withoutperinatal asphyxia:is it and additional marker of perinatal asphyxia? Acta Paediatr Jpn. 1998, 40:427-31.
  • 3[3]Akisu M, kultursay N, Coker L, et al. The effect of Lcarnitine on platelet activating factor concentration inthe immature rat model of hypoxic-ischemic brain injury. Acta Med Okayama. 1998,52:183-7.
  • 4[4]Liu XH, Eun BL, Siverstein FS, et al. The platelet-activating factor anlagonist BN52021 attenuates hypoxic-ischemic brain injury in the immature rat. Pediatr Res1996,40;797-803.
  • 5[5]Yue Tl, Feuerstein GZ. Platelet-activating factor, a putative neuromodulator and mediator in the pathophysiology of brain injury. Crit Rev Neurobiol, 1994, 8:1124.
  • 6[6]Furukawa M, lee EL, Johnston JM. Platelet-activatingfactorinduced ischemic bowel necrosis : the effect ofplatelet-activating factor acetylhydrolase, Pediatr Res,1993,34:237-41.
  • 7[7]Hsueh W, Caplan MS, Sun X, et al. Platelet-activatingfactor, tumor necrosis factor, hypoxia and necrotizingenterocolitis. Acta Paediatr Suppl, 1994,396:11-7.
  • 8[8]Caplan M, Hsueh W, kelly A, et al. Serm PAF acetylhydrolase increases during neonatal maturation.Prostaglandins, 1990,39:705-14.
  • 9[9]Caplan Ms,Lickerman M,Adler L,et al. The role of recombinant platelet-activating factor acetylhydrolase in aneonatal rat model of necrotizing enterocolitis, PediatrRes, 1997,42: 779-83.
  • 10[10]Cundell DR Gerard NP, Gerard C, et al. Strepto-coccus pneumoniae anchor to activated human cells by thereceptor for platelet-activating factor. Nature. 1995,377(6548):435-8.

共引文献48

同被引文献63

  • 1魏克伦,杨于嘉,姚裕家,杜立中,王庆红.中国住院新生儿流行病学调查[J].中国当代儿科杂志,2009,11(1):15-20. 被引量：211
  • 2张忠德,余亚雄,王怡平,廖贤平.先天性巨结肠肠炎与坏死性小肠结肠炎的病理比较[J].中华病理学杂志,1995,24(5):285-287. 被引量：1
  • 3吴斌,宋朝敏,王红,黄妙辉.双歧杆菌对新生大鼠坏死性小肠结肠炎肠损伤及肠组织血小板活化因子、肿瘤坏死因子α的影响[J].中华儿科杂志,2007,45(7):548-549. 被引量：4
  • 4Lin PW,Stoll BJ.Necrotising enterocolitis.Lancet,2006,368(9543):1271-1283.
  • 5Frost BL,Jilling T,Caplan MS.The importance of proinflammatory signaling in neonatal necrotizing enterocolitis.Semin Perinatol,2008,32(2):100-106.
  • 6Rabinowitz SS,Dzakpasu P,Piecuch S,et al.Platelet-activating factor in infants at risk for necrotizing enterocolitis.J Pediatr,2001 138(1):81-86.
  • 7Hsueh W,Caplan MS,Qu XW,et al.Neonatal necrotizing enterocolitis:clinical considerations and pathogenetic concepts.Pediatr Dev Pathol,2003,6(1):6-23.
  • 8Caplan MS,Simon D,Jilling T.The role of PAF,TLR,and the inflammatory response in neonatal necrotizing enterocolitis.Semin Pediatr Surg,2005,14(3):145-151.
  • 9Qu XW,Rozenfeld RA,Huang W,et al.The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat.Gut,1999,44(2):203-211.
  • 10Markel TA,Crisostomo PR,Wairiuko GM,et al.Cytokines in necrotizing enterocolitis.Shock,2006,25(4):329-337.

引证文献4

二级引证文献26

中国小儿急救医学
2008年 第1期

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