转染肝细胞生长因子基因对移植颗粒脂肪新生血管形成的影响
被引量:1
摘要
脂肪移植要取得进展,就要深入研究移植后的再血管化。我们以腺病毒为载体,把肝细胞生长因子(HGF)基因导入大鼠骨髓间充质干细胞(MSCs),然后与颗粒脂肪混合移植,充分发挥MSCs多项分化潜能和HGF强大的血管效应,旨在为颗粒脂肪移植建立新生血管诱导生物组织工程模式。
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2008年第8期1079-1079,共1页
Chinese Journal of Experimental Surgery
基金
全军“十一五”医学科研面上项目(06MA079)
甘肃省自然科学基金资助项目(3ZS061-A25-099)
参考文献6
-
1王有虎,刘毅,哈小琴.肝细胞生长因子在整形外科领域的研究进展[J].中国美容医学,2007,16(8):1155-1157. 被引量:6
-
2Taniyama Y, Morishita R, Aoki M, et al. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hind limb ischemia models:preclinical study for treatment of peripheral arterial disease. Gene Ther,2001,8 :181-189.
-
3何勇,周峻,陈勇,李海民,赵青川,窦科峰.活体转染肝细胞生长因子基因对小鼠急性肝功能衰竭的治疗作用[J].中华实验外科杂志,2005,22(8):941-943. 被引量:3
-
4Traktuev DO, Parfenova EV, Trachuk VA, et al. Adipose stromal cell-Plastic type of high therapeutic potential. Tsitologiia, 2006,48:82-94.
-
5王志刚,黄一东,欧慧芳,程可洛,梁克,吴铮.腺病毒携带肝细胞生长因子基因不同途径转染对大鼠急性缺血心肌的影响[J].中华实验外科杂志,2005,22(11):1372-1373. 被引量:7
-
6Langer S, Sinitsina I, Biberthaler P, et al. Revascularization of transplanted adipose tissue:a study in the dorsal skinfold chamber of hamsters. Ann Plast Surg,2002,48 : 53-59.
二级参考文献15
-
1哈小琴,苑宾,李元敏,劳妙芬,吴祖泽.Gene therapy for pathological scar with hepatocyte growth factor mediated by recombinant adenovirus vector[J].Science China(Life Sciences),2003,46(3):320-327. 被引量:16
-
2邱林,金先庆.转化生长因子β在创伤愈合、瘢痕增生以及骨形成方面的研究与进展[J].中国临床康复,2005,9(10):178-179. 被引量:17
-
3哈小琴,赵治华,吕同德,劳妙芬,吴祖泽.大鼠注射重组腺病毒Ad-HGF后血清中抗腺病毒抗体的检测[J].中国比较医学杂志,2006,16(9):515-517. 被引量:2
-
4周一军,王佳贺,张锦.肝细胞生长因子抗糖基化终产物诱导内皮细胞凋亡及分子机制[J].中国医科大学学报,2006,35(4):367-370. 被引量:3
-
5金丽娟,哈小琴,张诚,刘毅,吕同德.Ad-HGF修饰MSCs异体移植对烧伤创面愈合的作用[J].西北国防医学杂志,2007,28(1):12-15. 被引量:16
-
6He Y, Zhou J, Dou KF, et al. A rat model for acute hepatic failure.HBPD Int, 2003, 2:423-425.
-
7Funakoshi H, Nakamura T. Hepatocyte growth factor: from diagnosis toclinical applications. Cllnica Chimaca Acta, 2003,327 : 1-23.
-
8Kaido T, Imamura M. Hepatocyte growth factor: clinical implications in hepatobiliary pancreatic surgery, J Hepatobiliary Pancreat Surg, 2001,8 : 65-75.
-
9Kosai K, Matsumoto K, Funakoshi H) et al, Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology,1999, 30:151-159.
-
10Toshihiro F,Yoshiki S.Therapeutic angiogenesis in the ischemic canine heart induced by myocardial injection of naked complementary DNA plasmid encoding hepatocyte growth factor.Internet J Thoracic Cardiovascular Surgery,2002,124:1099-1151.
共引文献13
-
1金哲洙.肝细胞生长因子与肝损伤关系研究进展[J].延边大学医学学报,2007,30(4):307-309. 被引量:1
-
2杨庭树,李萍,李岩密,梁丽玲,张华威,易军,苟朋.肝细胞生长因子对心肌梗死后左心室收缩同步性的影响[J].中国组织工程研究与临床康复,2008,12(2):248-253.
-
3冯智,李世荣,曹川,王珍祥,陈艳清,戴霞,夏珊.HGF/c-met蛋白在人增生性瘢痕组织中定位与表达的研究[J].中国美容医学,2008,17(5):692-694.
-
4杨继武,周业庭,刘伟平,张立飞,姜志良.肝细胞生长因子治疗兔下肢缺血的实验研究[J].临床与实验病理学杂志,2008,24(5):589-592. 被引量:4
-
5郭万里,张宝林,侯秀英,桑金玲.肝细胞生长因子促进移植颗粒脂肪成活的实验研究[J].山西医药杂志(上半月),2009,38(2):128-129. 被引量:3
-
6杨继武,刘伟平,周业庭,张立飞,姜志良,邢壮杰.rhG-HGF联合成纤维细胞生长因子促进下肢血管新生的实验研究[J].中国普通外科杂志,2009,18(6):584-587. 被引量:6
-
7杨继武,周业庭,刘伟平,张立飞,姜志良,邢壮杰.重组人肝细胞生长因子联合粒细胞集落刺激因子对血管新生的影响[J].中华实验外科杂志,2010,27(6):842-842. 被引量:3
-
8雷霞,刘渤,伍津津,鲁元刚,杨亚东.siRNA c-Met腺病毒转染对人外泌汗腺上皮细胞增殖的影响[J].中国美容医学,2010,19(9):1324-1326.
-
9常仁安,陈钟,李志峰.急性肝衰竭大鼠载肝细胞生长因子纳米粒子肝细胞移植后有丝分裂指数和Ki-67表达变化及意义[J].中华实验外科杂志,2011,28(1):76-79. 被引量:3
-
10王家瑞,刘达恩,农庆文,梁坤兰,李顺堂,李开通.肝细胞生长因子对大鼠背部超长任意皮瓣存活率影响的实验研究[J].中国美容医学,2011,20(3):430-433. 被引量:3
同被引文献39
-
1Chang Q,Lu F.A novel strategy for creating a large amount of engineered fat tissue with an axial vascular pedicle and a prefabricated scaffold.Med Hypotheses,2012,79(2):267-270.
-
2Tanzi MC,Farè S.Adipose tissue engineering:state of the art,recent advances and innovative approaches.Expert Rev Med Devices,2009,6(5):533-551.
-
3Eto H,Kato H,Suga H,et al.The fate of adipocytes after nonvascularized fat grafting:evidence of early death and replacement of adipocytes.Plast Reconstr Surg,2012,129(5):1081-1092.
-
4Zuk PA,Zhu M,Mizuno H,et al.Multilineage cells from human adipose tissue:implications for cell-based therapies.Tissue Eng,2001,7(2):211-228.
-
5Tang W,Zeve D,Suh JM,et al.White fat progenitor cells reside in the adipose vasculature.Science,2008,322(5901):583-586.
-
6Strem BM,Zhu M,Alfonso Z,et al.Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of acute myocardial injury.Cytotherapy,2005,7(3):282-291.
-
7Bianchi F,Maioli M,Leonardi E,et al.A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates.Cell Transplant,2013,22(11):2063-2077.
-
8Li Q,Qi LJ,Guo ZK,et al.CD73+ adipose-derived mesenchymal stem cells possess higher potential to differentiate into cardiomyocytes in vitro.J Mol Histol,2013,44(4):411-422.
-
9Seo MJ,Suh SY,Bae YC,et al.Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo.Biochem Biophys Res Commun,2005,328(1):258-264.
-
10Yamamoto Y,Banas A,Murata S,et al.A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells.FEBS J,2008,275(6):1260-1273.
二级引证文献5
-
1苏鹏,张巍巍,余华伟,杨函.脂肪干细胞在人工骨支架诱导下的成骨效应[J].中国组织工程研究,2015,19(28):4493-4497. 被引量:1
-
2阳水发,易阳艳,黄艳,吴舒,王朝慧.人脂肪干细胞与不同浓度纤维蛋白胶的相容性研究[J].重庆医学,2017,46(2):165-168. 被引量:3
-
3朱元正,易阳艳,阳水发,张静,吴舒,王朝慧.携带肝细胞生长因子基因慢病毒转染人脂肪来源干细胞复合纤维蛋白胶支架构建可注射型组织工程脂肪的实验研究[J].中国修复重建外科杂志,2017,31(9):1111-1118. 被引量:4
-
4程彬,刘毅.CAL技术修复软组织缺损的临床应用进展[J].中国美容整形外科杂志,2018,29(3):182-183. 被引量:2
-
5刘鹏程,谭秋雯,张忆,王红,吕青.猪脂肪源基质水凝胶辅助游离脂肪移植的应用初探[J].中国修复重建外科杂志,2020,34(10):1322-1331.
-
1王有虎,刘毅.腺病毒介导的HGF转染骨髓间充质干细胞影响移植颗粒脂肪新生血管形成的初步研究[J].中国美容医学,2014,23(15):1260-1263. 被引量:1
-
2徐坚方,谭晓燕,林洁.注射法颗粒脂肪移植的临床应用[J].实用美容整形外科杂志,1995,6(1):18-20. 被引量:7
-
3孙哲,蒋爱梅.脂肪干细胞与碱性成纤维细胞生长因子在颗粒脂肪移植中应用的研究进展[J].医学综述,2012,18(15):2401-2403. 被引量:8
-
4李晶,薛斌.自体颗粒脂肪移植的研究进展[J].医学信息,2013(7):568-569.
-
5杜学亮,罗少军,郝新光,汤少明,梁杰.碱性成纤维细胞生长因子在颗粒脂肪移植后血运重建过程的作用[J].中华整形外科杂志,2005,21(2):128-131. 被引量:36
-
6赵正,崔文清,丁阿娟,高旭东.颗粒脂肪移植隆乳术11例体会[J].中国美容医学,2007,16(5):639-639.
-
7张文正,魏开斌.嗅鞘细胞联合移植治疗脊髓损伤现状[J].泰山医学院学报,2010,31(7):554-558.
-
8梁衍灿,陈伟良.茎突综合征病因的研究进展[J].临床口腔医学杂志,2009,25(9):574-575. 被引量:4
-
9刘萍,刘毅,刘莉,张瑞莉,陈元婕.颗粒脂肪移植术前注射量的评估[J].中国美容医学,2011,20(11):1702-1704. 被引量:9
-
10慈海,熊伟.提高自体游离脂肪移植成活率研究进展[J].大家健康(学术版),2012(2):59-61.