宫颈分泌物支原体检测及耐药性分析

Detection of Mycoplasma in Cervical Mucus and the Drug Resistance

目的了解女性泌尿生殖道感染患者解脲支原体(Uu)和人型支原体(Mh)感染及耐药情况。方法采用支原体鉴定药敏试剂盒,对598例女性泌尿生殖道感染患者标本进行培养及药敏试验。结果598例患者中检出Uu阳性229例(38.2%),Mh阳性8例(1.3%),Uu+Mh阳性49例(8.2%),总检出率47.8%(286例);药敏结果表明,Uu与Mh对交沙霉素,强力霉素,四环素等较为敏感,对氧氟沙星耐药率高。结论女性泌尿生殖道Uu和Mh感染率高,主要以Uu为主,Uu和Mh对多种抗菌药物耐药,其中以氧氟沙星为最高,单纯Uu、Mh和Uu+Mh的耐药率存在一定差异,治疗支原体感染以交沙霉素、强力霉素、四环素最好。

[ Objective] To understand the infection of Uu and Mh among the female patients with urogenital tract infection and the drug resistance. [ Methods] 598 specimens of the female patients with urogenital tract infection were collected, cultured and tested for drug sensitivity with mycoplasma test drug sensitivity kit. [ Results] Among the 598 specimens, 229 cases （38.2%） were detected with positive Uu, 8 cases （ 1.3% ） with positive Mh and 49 cases （8.1%） with both, the total detection rate was 47.8% （286 cases） ; the drug sensitivity test indicated that Uu and Mh were sensitive to josamycin, doxycycline and tetracyclin but were resistant to ofloxacin. [ConcIusion] The infection of Uu and Mh, Uu especially, is high among the female patients with urogenital tract infection; Uu and Mh have high drug resistance to many antibiotics, especially to ofloxacin; the drug resistance is different between simple Uu, Mh and Uu combined with Mh; josamycin, doxycycline and tetracycline are the best antibiotics to treat the infection of Mycoplasma.