降压胶囊联合尼莫地平治疗老年单纯收缩期高血压疗效及对其生活质量的影响

Effects of Jiangya Capsule Combined with Nimodipine on Depressurization and Quality of Life in Elderly Patients with Isolated Systolic Hypertension

目的观察降压胶囊联合尼莫地平对老年单纯收缩期高血压(EISH)患者的降压疗效以及生活质量的改善情况。方法采用随机、双盲、对照的试验设计方法,将120例EISH患者随机分为2组:降压胶囊联合尼莫地平治疗组(治疗组)60例,脱落6例,有54例进入统计;尼莫地平对照组(对照组)60例,脱落13例,有47例进入统计。治疗组口服降压胶囊联合尼莫地平胶囊,对照组口服尼莫地平胶囊联合降压胶囊模拟药,疗程为4周。观察患者治疗前后血压及生活质量变化。结果治疗组对收缩压的疗效优于对照组,组间比较差异有统计学意义(P<0.05);2组对舒张压的影响差异无统计学意义。治疗组降压总有效率为81.5%,对照组总有效率为51.1%,2组比较差异有统计学意义(P<0.01)。治疗组改善患者24h平均收缩压、白天平均收缩压、夜间平均收缩压均优于对照组(P<0.05);而2组舒张压变化比较差异无统计学意义(P>0.05)。治疗组改善阴虚阳亢证中医症状积分明显优于本组非阴虚阳亢证及对照组(P<0.05)。治疗组生活质量的改善也明显优于对照组(P<0.01或P<0.05)。结论降压胶囊联合尼莫地平对EISH患者有较好的降压疗效,明显改善患者的临床症状,提高EISH患者生活质量。

Objective To observe the effect on depressurization and quality of life through Jiangya capsule combined with nimodipine treatment. Methods Randomized, blind and control trial was applied. One hundred and twenty elderly isolated systolic hypertension （EISH） patients were randomly assigned to Jiangya capsule combined with nimodipine group （treatment group） 60 cases （6 cases were lost and 54 cases were in analysis） or nimodipine group （control group） 60 cases （13 cases were lost and 47 cases were in analysis）. Treatment group was administrated with Jiangya capsule and nimodipine, and control group was administrated with nimodipine and Jiangya capsule placebo. The course of treatment was 4 weeks. The blood pressure and quality of life of the two groups were observed before and after treatment. Results SBP was obviously decreased in treatment group compared with control group （P〈0.05）, and there was no effect on DBP of the two groups. The total effective rate of depressurization in treatment group was 81.5%, and in control group was 51.1%, and there was signffcant difference （P〈0.01）. 24 hour mean SBP, day mean SBP, night mean SBP in treatment group were improved and superior to control group （P〈0.05）, and there was no effect on DBP of the two groups （P〉0.05）. Symptom scores of yin deficiency and yang hyperactivity syndrome in treatment group was improved and superior to the other syndromes in treatment group and control group （P〈0.05）. Quality of life in treatment group improved and was superior to control group （P〈0.01 or P〈0.05）. Conclusions Jiangya capsule combined with nimodipine has satisfying depressurization effect on EISH patients, and it can improve the clinical symptoms and quality of life.