摘要
81例经胃镜证实的HP阳性十二指肠溃疡患者,随机分成二组分别接受兰索拉唑三联或二联疗法根除HP治疗。服法:三联组兰索拉唑30mg,每日2次,阿莫西林0.5g及甲硝唑0.4g,每日3次;二联组兰索拉唑服法同上,阿莫西林0.5g,每日4次。疗程均为10d.结果:三联组根除率为95%(38/40),高于二联组80.5%(33/41)(P<0.05);溃疡愈合率分别为87.5%及87.8%;副反应发生率分别为15%(6/40)及4.9%(2/41),P>0.05。结果表明:兰索拉唑三联疗法具有症状缓解迅速、HP根除率高、副反应轻、依从性好等优点,是一种较理想的根除HP治疗方案。
Elghty onc patlents with active duodenal ulcers and Helicobacter pylori (HP) infection proved by histology, ure ase tcst and culture were randomized into two groups. Group A received 30mg Lansoprazole (LAN) twice daily com blned with 500mg amoxycilline and 400mg metronidazole three times daily for ten days. Group B reteived 30mg LAN twice daily combmed with 500mg amoxycilline four times daily for ten days. The rates of HP eradication were 95 % (38/40 ) in Group A, and 80. 5 % (33/41 ) in Group B (P < 0. 05 ). The ulcer healing rate in Group A was 87. 5 % and in Group B was 87. 8 % (P >0. 05 ). Side effects werc observed in 15 % (6/40) of Group A and 4. 9 % (2/41 ) of Group B(P >0.05 ).In conclusion, Lansoprazole triple therapy with amoxycilline and metronidazole appears to be an effcctive and Well tolerated treatment regimen for the eradication of HP infection.
出处
《中国内镜杂志》
CSCD
1997年第5期16-16,18,共2页
China Journal of Endoscopy