兰索拉唑三联疗法根治胃幽门螺杆菌的疗效观察

EFFICACY OF LANSOPRAZOLE TRIPLE THERAPY IN THE ERADICATION OF HELICOBACTER PYLORI

81例经胃镜证实的HP阳性十二指肠溃疡患者，随机分成二组分别接受兰索拉唑三联或二联疗法根除HP治疗。服法：三联组兰索拉唑30mg，每日2次，阿莫西林0．5g及甲硝唑0．4g，每日3次；二联组兰索拉唑服法同上，阿莫西林0．5g,每日4次。疗程均为10d.结果：三联组根除率为95％（38／40），高于二联组80．5％（33／41）（P＜0.05）；溃疡愈合率分别为87．5％及87．8％；副反应发生率分别为15％（6／40）及4．9％（2／41），P＞0．05。结果表明：兰索拉唑三联疗法具有症状缓解迅速、HP根除率高、副反应轻、依从性好等优点，是一种较理想的根除HP治疗方案。

Elghty onc patlents with active duodenal ulcers and Helicobacter pylori (HP) infection proved by histology, ure ase tcst and culture were randomized into two groups. Group A received 30mg Lansoprazole (LAN) twice daily com blned with 500mg amoxycilline and 400mg metronidazole three times daily for ten days. Group B reteived 30mg LAN twice daily combmed with 500mg amoxycilline four times daily for ten days. The rates of HP eradication were 95 % (38/40 ) in Group A, and 80. 5 % (33/41 ) in Group B (P < 0. 05 ). The ulcer healing rate in Group A was 87. 5 % and in Group B was 87. 8 % (P >0. 05 ). Side effects werc observed in 15 % (6/40) of Group A and 4. 9 % (2/41 ) of Group B(P >0.05 ).In conclusion, Lansoprazole triple therapy with amoxycilline and metronidazole appears to be an effcctive and Well tolerated treatment regimen for the eradication of HP infection.