格林—巴利综合征211例分析

Analysis of 211 Cases of GBS

分析211例格林巴利综合征患者，男多于女（2．1／1），10～30岁多发。约63％有前驱症状，主要表现在呼吸道和胃肠道。多以迅速加重的肌无力为主诉（95．3％），体征有深反射消失或减退（90％），感觉症状较轻（42．6％）。脑脊液有蛋白-细胞分离（83．8％）。IgG24小时合成率与病情及病程相关。电生理表现脱髓鞘特征（93．5％），病理上表现为节段性脱髓鞘和单核细胞浸润（100％）。

In a survey of 211 cases with GBS, males were dorminant than females (2. 1/1) and the peak age were 10 to 30. Approximately 63% had an antecedent events, mainly respiratory and gastrointestinal infections. Motor weakness usually developed repidly and was chief complaint (95. 3% ). Deep tendon reflexes were reduced even absent (90%), but sensory symptoms were mild (42. 6%). The CSF showed albumino cytologic dissociation with increased protein (83. 8% ) and no or very few cells. The CSF twenty four hour synthesis rate of IgG correlates well with course and severity of disease. The electrophysiological feature was demyelination (93. 5% ), pathological features of sural nerve biopsy were segmental demyelination and mononuclear cell infiltration (100% ).