急性脑梗死给予依达拉奉对血清超氧化物歧化酶、特异性烯醇化酶的影响及临床意义

Impact and Clinical Significance of Edaravone on Serum Superoxide Dismutase and Specific Enolase for Acute Cerebral Infarction

目的:研究依达拉奉对急性脑梗死患者血清超氧化物歧化酶(SOD)、神经元特异性烯醇化酶(NSE)的影响,分析其临床意义。方法:120例急性脑梗死患者随机分为2组,2组均予常规治疗,治疗组在此基础上予依达拉奉30mg 静滴,2/d,连续14d,检测治疗前、发病72h 和治疗后7d、14d 患者血清 SOD、NSE 的浓度。结果:治疗组与对照组比较于发病72h、治疗后7d 血清 SOD高、NSE 浓度低,均有显著性差异(P<0.01)。结论:急性脑梗死患者依达拉奉治疗可增强自由基清除能力,保护神经元。

Objective ：To study the impact of edaravone on superoxide dismutase （SOD） and neuron-specific enotase （NSE） for patients with acute cerebral infarction. To analyze its clinical significance. Methods： 120 cases of acute cerebral infarction patients were randomly divided into two groups. Group 2 were gaven conventional treatment. The treatment group was given edaravone 30 mg intravenous infusion. 2 times / day, for 14 days, on the basis of regular treatment. To test SOD, NSE concentration before treatmem, 72 hours after the incidence and treatment after 7 days and 14days. Results： serum SOD is higher and NSE concentration low when the treatment group is compared with the control group 72 hours after incidence and 7 days after treatment. There was significant difference （P〈0.01）. Conclusion： Taking edaravone treatment can enhance the free radicals＇ s ehmination ability and to protect neurons for patients with acute cerebral infarction.