石家庄市桥东区12116例小学生乙肝表面抗原及表面抗体检测结果分析

Clinical Study On HBsAg ＆HBsAb Examination Results In Primary Of 12116 Cases in Qiao Eastern District of Shijiazhuang

目的：了解石家庄市桥东区1-6年级小学生乙肝表面抗原和表面抗体阳性率情况，为乙肝疫苗加强免疫提供依据。方法：用酶联免疫法（ELISA）检测HBsAg、抗-HBs.结果：共检测1-6年级学生12116人，其中HBsAg阳性人数46人，阳性率为0.38%;HBsAg阴性的12070名学生中，抗-HBs阳性人数5613人，总阳性率46.50%。为进一步了解不同年龄组、不同性别的儿童抗体阳性率情况，经X^2检验，男女儿童抗体阳性率差异对比X^2=0.87,P＞0.05，差别无统计学意义。6-9岁组与10-11岁组儿童抗体阳性率差异对比X^2=28.30,P＜0.005,差别有统计学意义。结论：乙肝疫苗接种率有待继续提高。应根据抗-HBs检测结果，及时给予乙肝疫苗补种和加强。

Objective：To understand the situation of hepatitis B surface antigen（HBsAg）and hepatitis B surface antibody （antiHBs）positive rates of Shijiazhuang Shiqiao Eastern 1 to 6-year primary school students,and for the purpose of providing the basis for the hepatitis B vaccine strentthening immunity.Methods：Applied the enxyme-linked immunosorbent aasay（ELISA）to detect HBsAg,anti-HBs、Results：12116 students of 1 to 6 grades were detected,46 of which were HBsAg-positive,the positive rate was 0.38%;12070 students were HBsAg negative and the anti-HBs positive number was 5613,the positive rate was 46.50%.To further understand the anti-HBs positive rate from diferent age groups and different gender of the children,the X^2 test were used,and the gender anti-HBs positive rate Differences was：X^2=0.87,P〉0.05,no statistically signficant difference.6to9-year-old group and 10 to 11-year-old group of children-positive rate Differences was X^2=28.30,P〈0.005,which was of statistically significang difference.Conclusion：The hepatitis Bvaccination rate iscontinued to be improved.Based on the anti-HBs test resnlts,the hepatitis B vaccine should be replant and strengthened in time.