摘要
研究观察中药制剂清君饮对动物药物依赖性的影响。用逐次逐日增加吗啡注射剂量的方法造成大鼠的吗啡依赖性模型后，又分别分为中药大、小剂量组，吗啡维持组，空白对照组，再给予腹腔注射纳洛酮给予催瘾，观察经不同药物处理后动物的戒断症状反应。结果表明：中药能明显抑制成瘾大鼠的戒断症状。主要症状积分值的降低与空白对照组相比有显著差异（Ｐ＜０．０１）并能促进动物体重的恢复。
The effect of herbal Preparation Qing Jun Yin (QJY) on the drug dependence of animal models was studied.After the morphinistic models of white rats and mice were made by ever increasing doses of morphine each time, the animals were divided into large dose QJY group, small dose QJY group, sustained morphine group, and control group.The withdrawal symptoms were observed after naloxone was given to the animals intraperitoneally.The results showed that the QJY groups withdrawal symptoms of the addicted white rats were alleviated, the number of jumps of the addicted mice was reduced, the scores of the principal symptoms of the animals were decreased, while the body weights of the animals were gained, comparing with the control group, the difference was significant ( P <0 01).The effects of the QJY enhanced in the large dose group, which suggests that the QJY has abstinence effects.
基金
广州军区科研基金资助
关键词
清群饮
戒断综合征
戒毒
中药
Qing Jun Yin
morphine addiction
abstinence syndromeof
