期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胞质紧密粘连蛋白1的研究现状 被引量：2

Recent Researches on Zonula Occludens-1
下载PDF
导出
摘要 胞质紧密粘连蛋白1(ZO-1)是多域蛋白家族膜结合鸟苷酸激酶同系物中的一员,作为紧密连接的组成成分在组织分化和器官发生发面起关键作用,同时ZO-1的改变与细胞通透性的增加有关。ZO-1在包括肾、胎盘、血脑屏障等许多组织中表达,可与紧密连接上的很多跨膜蛋白相互作用。 Zonula occludens-1 belongs to a family of muhi-domainproteins known as the membrane-associated guanylate kinase homologues（MAGUKs）. It is tight junction constituent and therefore play a pivotal role in tissue differentiation and organogenesis. Alterations of ZO-1 are associated with increased paracellular permeability. ZO-1 expresses in some tissues such as kidney, human placenta and blood-brain-barrier. ZO-1 has been demonstrated to interact with the tranmembrane proteins localizing at tight junctions.
作者 闫洪领 王季猛
机构地区 南华大学附属第二医院内分泌科
出处 《医学综述》 2008年第17期2589-2591,共3页 Medical Recapitulate
关键词 胞质紧密粘连蛋白1 紧密连接 上皮细胞 Zonula occludens-1 Tight junctions Epithelial cells
分类号 R335 [医药卫生—人体生理学]
  • 相关文献

参考文献1

二级参考文献7

  • 1Neumann-Haefelin T, Kastrup A, de Crespigny A, et al. Serial MRI after transient focal cerebral ischemia in rats Dynamics of tissue injury, Blood-brain barrier damage, and Edema formation[J]. Stroke, 2000, 31:1965-1973.
  • 2Nishigaya K, Yagi S, Sato T, et al. Impairment and restoration of the endothelial blood-brain barrier in the rat cerebral infarction model assessed by expression of endothelial barrier antigen immunoreactivity[J]. Acta Neuropathol, 2000, 99:231-237.
  • 3Baskawa MK, Dogan A, Rao AM, et al. Neuroprotective effects of citicotine on brain edema and blood-brain barrier breakdown after traumatic brain injury[J]. J Neurosurg, 2000, 92:448-452.
  • 4Bederson JB, Pitts LH, Germano SM, et al. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats[J]. Stroke, 1986, 17:1304-1308.
  • 5Albayrak S, Zhao Q, Siesjo BK, et al. Effect of transient focal ischemia on Blood-brain barrier permeability in the rat: correlation to cell injury[J]. Acta Neuropathol, 1997, 94:158-163.
  • 6Germano A, d'Avella D, Imperatore C, et al. Time-course of blood-brain barrier permeability changes after experimental subarachnoid haemorrhage[J]. Acta Neurochir(Wien), 2000, 142:575-581.
  • 7Riesen FK, Rothen RB, Wunder AH. A ZO1-GFP fusion protein to study the dynamics of tight junctions in living cells[J]. Histochem Cell Biol, 2002, 117:307-315.

共引文献15

同被引文献24

  • 1邵立健,朱清仙.一种跨膜蛋白——闭锁蛋白的研究现状[J].国外医学（生理病理科学与临床分册）,2004,24(3):263-266. 被引量：8
  • 2慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华结核和呼吸杂志,2007,30(1):8-17. 被引量：8235
  • 3BARNES P J,SHAPIRO S D,PAUWELS R A. Chronic obstructive pulmonary disease:molecular and cellular mechanisms [ J ]. Eur Respir J, 2003,22 : 672 - 688.
  • 4YEAMAN C, GRINDSTAFF K K,NELSON W J. NEW Perspectives on mechanisms involved in generating epithelial cell polarity[J]. Physiol Rev, 1999,79( 1 ) :73 - 98.
  • 5SCHNEEBERGER E E, LYNCH R D. The tight junction : a multifunctional complex[ J ]. Am J Physiol Cell Physiol, 2004,286:1 213- 1 228.
  • 6BOUVRY D, PLANE'S C, MALBERT-COLAS L, et al. Hypoxia-induced cytoskeleton disruption in alveolar epithelial cells [J]. Am J Respir Cell Mol Biol,2006,35: 519 - 527.
  • 7VANDRIESSCHE W, KREINDLER J L, MALIK A B, et al. Interrelations/cross talk between transcellular transport function and paracellular tight junctional properties in lung epithelial and endothelial barriers [J]. Am J Physiol Lung Cell Mol Physiol, 2007,293 : 520 - 524.
  • 8SOIN! Y. Claudins in lung diseases[J]. Respiratory Research ,2011,12:1 - 11.
  • 9李玉英,陈枫,谭红梅,王宋平,黄桂君,钱桂生,王关嵩.大鼠Occludin基因克隆及其在肺泡Ⅱ型上皮细胞中的表达[J].重庆医学,2008,37(19):2203-2204. 被引量：2
  • 10赵晓云,李波,曹立业,方文刚,朱莉,陈誉华.小细胞肺癌细胞诱发人脑微血管内皮细胞紧密连接的开放[J].解剖科学进展,2009,15(2):183-187. 被引量：5

引证文献2

二级引证文献5

医学综述
2008年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部