摘要
新生儿可通过胎盘获得不同种类的IgG抗体，这些抗体的量及其衰减率因种类不同而存在差异。母源性抗体能保护新生儿和婴幼儿抵御相应病原体的感染，但也严重影响婴幼儿疫苗接种后主动免疫应答，母源性抗体浓度越高，其影响越大。了解母源性抗体对新生儿疫苗接种的影响，有助于母体或新生儿疫苗的研制，对确立有效的免疫方案具有重要的指导意义。
出处
《中华围产医学杂志》
CAS
2008年第4期274-276,共3页
Chinese Journal of Perinatal Medicine
基金
南京市医学科技发展项目基金（ZKM06050）
江苏省医学重点学科--南京市鼓楼医院母-胎医学中心建设经费
参考文献27
-
1Dancis J, Lind J, Oratz M, et al. Placental transfer of proteins in human gestation. Am J Obstet Gynecol, 1961,82: 167-171.
-
2Bright NA, Oekleford CD. Cytotrophoblast eells..a barrier to maternofetal transmission of passive immunity. J Histoehem Cytochem, 1995,43:933-944.
-
3Malek A, Sager R, Kuhn P, et al. Evolution of maternofetal transport of immunoglobulins during human pregnancy. Am J Reprod Immunol, 1996, 36:248-55.
-
4Weeratna RD, Brazolot Millan CL, McCluskie MJ, et al. Priming of immune responses to hepatitis B surface antigen in young mice immunized in the presence of maternally derived antibodies. FEMS Immunol Med Microbiol, 2001,30: 241- 247.
-
5Derya A, Necmi A, Emre A. Decline of maternal hepatitis A antibodies during the first 2 years of life in infants born in Turkey. AmJ TropMed Hyg, 2005,73:457-459.
-
6Caceres VM, Strebel PM, Sutter RW, et al. Factors determining prevalence of maternal antibody to measles virus throughout infancy:a review. Clin Infect Dis, 2000,31: 110- 119.
-
7Baintner K. Transmission of antibodies from mother to young:Evolutionary strategies in a proteolytic environment. Vet Immunol Immunopathol, 2007,117 : 153-161.
-
8Leitner K, Ellinger A, Zimmer KP, et al. Localization of beta 2-microglobulin in the term villous syncytiotrophoblast. Histochem Cell Biol, 2002,117 : 187-193.
-
9Firan M, Bawdon R, Radu C, et al. The MHC class Ⅰ-related receptor, FeRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans. Int Immunol, 2001, 13:993-1002.
-
10Gafencu A, Heltianu C, Burlacu A, et al. Investigation of IgG receptors expressed on the surface of human placental endothelial cells. Placenta, 2003,24 : 664-676.
同被引文献16
-
1魏素花,武巧珍,胡娅莉,叶晓东.母源性抗-HBs对婴儿乙型肝炎疫苗接种效果的影响[J].解放军护理杂志,2009,26(10):1-4. 被引量：2
-
2梁晓峰,陈园生,王晓军,贺雄,陈丽娟,王骏,林长缨,白呼群,严俊,崔钢,于竞进.中国3岁以上人群乙型肝炎血清流行病学研究[J].中华流行病学杂志,2005,26(9):655-658. 被引量：967
-
3[4]O'Brien K L,Moisi J,Moulton L H,et al.Predictors of pneumococcal conjugate vaccine immunogenicity among infants and toddlers in an American Indian PnCRM7 efficacy trial[J].J Infect Dis,2007,196(1):104-114.
-
4[5]Bernardi F,Ito F H.Maternal antibody passively transferred interferes with rabies vaccination in hamsters[J].Comp Immunol Microbiol Infect Dis,2000,23(3):185-195.
-
5[6]Bell B P,Negus S,Fiore A E,et al.Immunogenicity of an inactivated hepatitis A vaccine in infants and young children[J].Pediatr Infect Dis J,2007,26(2):116-122.
-
6[7]Rosendahl C,Kochen M M,Kretschmer R,et al.Avoidance of perinatal transmission of hepatitis B virus:is passive immunisation always necessary?[J].Lancet,1983,1(8334):1127-1129.
-
7[8]Lee G C,Hwang L Y,Beasley R P,et al.Immunogenicity of hepatitis B virus vaccine in healthy Chinese neonates[J].J Infect Dis,1983,148(3):526-529.
-
8[9]Zanetti A R,Dentico P,Del Vecchio Blanco C,et al.Multicenter trial on the efficacy of HBIg and vaccine in preventing perinatal hepatitis B final report[J].J Med Virol,1986,18(4):327-334.
-
9[10]Weeratna R D,Brazolot Millan C L,McCluskie M J,et al.Priming of immune responses to hepatitis B surface antigen in young mice immunized in the presence of maternally derived antibodies[J].FEMS Immunol Med Microbiol,2001,30(3):241-247.
-
10[11]Lai C L,Yeoh E K,Chang W K,et al.Use of the hepatitis B recombinant DNA yeast vaccine (H-B-VAX II) in children:two doses vs three doses of 5 micrograms regime;an interim report[J].J Infect,1986,13(Suppl A):19-25.
引证文献3
-
1魏素花,武巧珍,胡娅莉,叶晓东.母源性抗-HBs对婴儿乙型肝炎疫苗接种效果的影响[J].解放军护理杂志,2009,26(10):1-4. 被引量：2
-
2王育新,张广阳.77例24小时内新生儿母源性抗-HBs检测报告[J].河南预防医学杂志,2017,28(5):363-364.
-
3陆利霞,王育新,沈德新,李金芝,张广阳.77例生后24小时内新生儿母源性抗-HBs的检测报告[J].哈尔滨医药,2016,36(S1):27-27.
-
1龙江.腺病毒有望成为新生儿疫苗的载体[J].传染病网络动态,2003(12):1-1.
-
2郑秀芳,姜惠波,于健,李秀芳,王建国,王书江,赵惠云.乙肝疫苗不同的免疫方案阻断乙肝母婴传播301例效果观察及5年随访[J].河北医药,1997,19(5):260-261.
-
3蔡辉儒.新生儿疫苗，注射还是服糖丸[J].中国家庭医生,2015,0(22):42-43.
-
4杜漫,江建宁,刘宇,王慧雯,李慧姣.长期应用阿德福韦酯抗病毒方案对慢性乙型肝炎患者肾功能的影响及其危险因素分析[J].广西医学,2017,39(4):444-446. 被引量：2
-
5张红艳,贾丽霞,赵晓唐,高丽萍.铁强化盐与普通碘盐中碘衰减率的比较[J].环境与健康杂志,2008,25(7):635-636.
-
6肝硬变[J].国外科技资料目录（医药卫生）,2000(11):52-52.
-
7邵志萍,欧阳佩英.一种新生和乙型肝炎疫苗免疫方案的长期效果考核[J].中华实验和临床病毒学杂志,1996,9(A00):41-43. 被引量：1
-
8刘春梅,聂秀玲,孙丽荣.非酒精性脂肪肝患者肝脏脂肪含量变化与糖代谢的关系[J].中国慢性病预防与控制,2014,22(1):9-13. 被引量：7
-
9孙宝剑,陈文学.农村儿童风疹抗体水平调查[J].江苏预防医学,2003,14(2):51-51.
-
10周立文,林春燕,马焱,孙莲英.海南省婴幼儿乙型肝炎病毒表面抗原携带情况分析[J].疾病监测,2002,17(4):144-145. 被引量：1
