氟苯尼考与4种中药联用对鳗鲡致病菌的抑制作用

Inhibition of Pathogenic Bacteria of Eels by the Combination of Florfenicol and Four Chinese Herbal Medicines

在鳗鲡体外采用琼脂培养法测定了氟苯尼考、大黄、黄连、黄芩、黄柏5种药物单用与联用对24株致病菌的最小抑菌浓度和最小杀菌浓度,结果表明:单用时,24株致病菌对氟苯尼考敏感(MIC≤8μg/mL)的有16株;对大黄、黄连、黄芩和黄柏敏感(MIC≤50 mg/mL)的分别有18株、21株、20株和2株.氟苯尼考分别与大黄、黄连、黄芩、黄柏联用时,共筛选出34种联用复方对15株致病菌有协同和相加作用.

We studied the minimal inhibitory concentration （MIC） and minimal bactericidal concentration （MBC） of florfenicol, Pheum officinale B. , Coptis chinensis F. , Scutellaria baicalensis G. , and Phellodendron anurense R. against 24 pathogenic bacteria of eels on the agar plates is studied. The results showed： of all these 24 strains pathogens, 16 strains were susceptible to florfenicol. There were 18, 21, 20 and 2 strains which were susceptible to Pheum officinale B. , Coptis chinensis F. , Scutellaria baicalensis G. , and PheUodendron anurense R. respectively. There were 34 compounds combinating florfenicol and one of the four Chinese herbal medicines showing synergism or addition effects on 15 strains pathogens.