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尿IL-6监测对肾移植术后急性排斥反应的诊断价值 被引量：2

Detection of urinary interleukin-6 and its clinical significance to predict acute rejections after renal transplantion
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摘要 目的探讨肾移植患者手术前后尿液中IL-6的变化及临床意义。方法采用ELISA法，动态监测患者移植手术前后尿液中IL-6的浓度。结果尿液中IL-6的浓度在肾移植术后第1天明显升高。急性排斥反应前1～2天尿液中IL-6的浓度有不同程度的升高，抗排斥治疗后迅速下降。结论动态监测尿IL-6是早期诊断肾移植术后急性排斥反应的一个较好的参考指标。 Objective To investigate the change of urinary interleukin-6 in the receptors after renal transplantation and to evaluate its contribution to predict acute rejections. Methods The urinary interleukin-6 were detected by enzyme linked immunosorbent assay（ELISA） and its clinical significance was analyzed combined with occurrence of acute rejections. Results Urinary interleukin- 6 1 day after transplantation in all receptors was higher than that before transplantation and its level began increasing 1-2 days before acute rejection（P〈0.01）. Conclusion Urinary interleukin-6 may play significant role for the prediction of the rejections and the increased survival rate of graft.
作者 项贵明 李阳 姚磊 朱鹏 蒲晓允
机构地区 第三军医大学新桥医院检验科
出处 《重庆医学》 CAS CSCD 2008年第17期1960-1960,1963,共2页 Chongqing medicine
关键词 肾移植 急性排斥反应 白细胞介素-6 renal transplantation acute rejection interleukin-6
分类号 R699.2 [医药卫生—泌尿科学]
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参考文献5

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  • 3Kwon O, Molitoris BA,Pescovitz M, et al. Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after injury in renal grafts[J]. Am J Kidney Dis, 2003,41(5) :1074.
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共引文献13

同被引文献13

  • 1于立新,徐健,白喜文,罗永礼,潘光辉,马俊杰,邓文锋,叶桂荣.尸体肾移植术后137例急性排斥反应的治疗体会[J].中华泌尿外科杂志,1994,15(1):20-21. 被引量：5
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二级引证文献1

重庆医学
2008年 第17期

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