脂肪细胞因子瘦素、肿瘤坏死因子与痰湿证多囊卵巢综合征的相关研究

The Correlation Research between Leptin,TNF-α and Phlegmatic Hygrosis Syndrome in Polycystic Ovarian Syndrome

目的:探讨瘦素(Leptin)、肿瘤坏死因子(TNF-α)与痰湿证多囊卵巢综合征(PCOS)的关系。方法:收集符合PCOS诊断标准和痰湿证中医辨证标准的研究对象22例,同时收集痰湿体质的正常人和无证可辨的正常人各20例作对照,测定三组研究对象的血清Leptin、TNF-α水平。结果:血清Leptin、TNF-α水平在痰湿证PCOS组明显高于痰湿对照组及正常对照组(P<0.05),在痰湿对照组明显高于正常对照组(P<0.05);痰湿证PCOS患者Leptin、TNF-α水平与BMI呈显著正相关关系,r=0.617,0.547,P<0.05;与ISI呈显著负相关关系,r=-0.577,-0.465,P<0.05。结论:痰湿证PCOS患者具有HI、胰岛素抵抗(IR)特点,血清Leptin、TNF-α水平升高可能与IR的发生关系密切。

Objective： to approach the relation of Leptin, TNF-α and phlegmatic hygrctsis syndrome in PCOS. Method： 22 cases of PCOS and phlegmatic hygrcrsis syndrome were study obiect and 20 cases of phlegmatic hygrctsis constitutional people and none syndrome person was control. The Leptin and TNF-α was detected. Result： The Leptin and TNF-α was higher in PCOS of phleg- matic hygrosis syndrome than control and higher in phlegmatic hygrosis syndrome than none syndrome person. The Leptin, TNF-α and BMI was pesitive correlation in PCOS of phlegmatic hygrctsis syndrome（r = 0.617, 0. 547, P 〈 0.05） and the Leptin, TNF-α and ISI was negative correlation （r= - 0.577, - 0.465, P〈0.05）. Conclusion： PCOS of phlegmatic hygrosis syndrome patients have the HI and IR feature, the happening of IR has the relationship to higher of Leptin and TNF-α.