四型肽精氨酸脱氨酶在类风湿性关节炎中的作用
摘要
类风湿性关节炎（rheumatoid arthritis．RA）是一种世界性疾病，是以关节滑膜为主要靶组织的慢性系统性炎症性的自身免疫性疾病，主要侵犯手足小关节。由于关节的慢性炎症，导致关节结构的破坏、畸形和功能丧失，具有较高的致残性。其确切的病因和发病机制至今尚未阐明，目前认为它是多种遗传因素和环境因素共同作用所导致的自身免疫性疾病。RA在自身免疫性结缔组织病中其患病率居首位，全世界的患病率大约为0．5％-1％．成年人发病率大约0．3‰。
出处
《现代医药卫生》
2008年第17期2608-2609,共2页
Journal of Modern Medicine & Health
参考文献13
-
1Yamada R,Suzuki A,Chang X, et al.Citrullinated proteins in rheumatoid arthritis[J].Front Biosci ,2005,10:54.
-
2Vossenaar ER,Zendman AJ ,van Venrooij WJ.Citrulllnation,a possible functional link between susceptibility genes and rheumatoid arthritis[J].Arthritis Res Ther,200d,6:1.
-
3Arita K, Hashimoto H, Shimizu T,et al.Structural basis for Ca^2-induced activation of human PAD4[J]. Arthritis Rheum,200.4,1 1:777.
-
4Vossenaar ER, Radstake TR, van der Heijden A,et al. Expression and activity of citrullinatlng peptidylarginine deiminase enzymes in monocytes and macrophages[J].Ann Rheum Dis,2004,63:373.
-
5Lundberg K,Nijenhuis K,Vossenaar ER,et al.Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity[J]. Arthritis Res Ther,2005,7:458.
-
6Barton A, Bowes J, Eyre S,et al.Funetional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population[J]. Arthritis Rheum, 2004,50:1117.
-
7Caponi L,Petit-Teixeira E,Sebbag M,et al. A family based study shows no association between rheumatoid arthritis and the PAD14 gene in a white French population[J].Ann Rheum Dis, 2005,64:587.
-
8Harney SM, Meisel C, Sims AM ,et al.Genetic and genomic studies of PAD14 in rheumatoid arthritis[J]. Rheumatology,2005,44:869.
-
9Martinez TW,Valdivia A, Piascual-Salcedo D,et al. PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population[J]. Rheumatology ,2005,44:1263.
-
10Barton A, Bowes J,Eyre S, et al.lnvestigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthfitis[J].Ann Rheum Dis,2005,64:1311.
-
1王昆润.测定胸膜渗出物的腺苷脱氨酶辅助诊断结核性胸膜炎[J].国际呼吸杂志,1995,0(4):215-215. 被引量：6
-
2冯晓朦,王晶莹,时景伟,李威,高申,冯雪飞,谢风.血清ADA水平和T-spot.TB联合检测在肺结核诊断中的应用[J].吉林大学学报（医学版）,2016,42(2):306-310. 被引量：24
-
3李京红,张琳,李军.脑脊液腺甘脱氨酶及结核抗体测定在结核性脑膜炎中的诊断价值[J].实用神经疾病杂志,2004,7(6):95-96. 被引量：1
-
4王百龄,王增祥,谢树莲.血清腺苷脱氨酶对肝脏疾病的诊断研究[J].实用肝脏病杂志,1996,1(1):45-46.
-
5冀燕民,王琪,刘莹.对结核性与恶性胸液鉴别的临床观察[J].临床肺科杂志,2000,5(3):214-214.
-
6专家面对面——本期话题：类风湿性关节炎[J].大众健康,2003(10):52-53.
-
7王立强,孙晓玲,沈黎云,卢晓霞,迟宝荣.不同肝病患者血清谷氨酸脱氨酶测定及临床意义[J].中国实验诊断学,2000,4(6):282-282.
-
8乙肝病毒G至A的超突变[J].传染病网络动态,2005(5):6-7.
-
9朱晓萍,张锦,郑西卫,吴振裘,潘月英.多项指标测定对胸腔积液鉴别诊断价值研究[J].肺癌杂志,1999,2(2):77-79. 被引量：6
-
10她的症状属于类风湿性关节炎吗[J].家庭健康（医学科普）,2005(5):48-48.
