摘要
目的:建立注射用七叶皂苷钠的溶血与凝聚检查法。方法:体外试管法采用《中国药典》2005年版一部附录ⅩⅧB中药注射剂安全性检查法应用指导原则"溶血与凝聚检查法",参照中华人民共和国国家食品药品监督管理局制定《化学药物刺激性、过敏性和溶血性研究技术指导原则》相关内容。结果:当浓度为0.04g·L-1,体积为0.3mL时,在37℃3h内,注射用七叶皂苷钠不对兔红细胞产生溶血与凝聚作用。结论:可选择浓度为0.04g·L-1,体积为0.3mL的注射用七叶皂苷钠生理盐水溶液,按规定的方法进行溶血与凝聚检查。
Objective: To Establish haemolysis and blood cell agglutination test on Sodium Aescinate for Injection. Method: According to the haemolysis and blood cell agglutination test in Chinese Pharmacopoeia 2005 edition. Results: It was proved that Sodium Aeseinate concentration was 0. 04 g·L^-1, 0. 3 mL solution caused no haemolysis and blood cell agglutination within 3 hours in vitro. Conclusion : Haemolysis and blood cell agglutination test on Sodium Aescinate for Injection was 0. 04 g·L^-1 ,0. 3 mL solution caused no haemolysis and blood cell agglutination within 3 hours in vitro.
出处
《中国药品标准》
CAS
2008年第4期283-286,共4页
Drug Standards of China