大黄对危重症患者的治疗作用及机制研究

Initial Study of Radix et Rhizoma RHei’s Regulating Function and Its Mechanism on Severe Cases

目的:观察大黄对合并呼吸衰竭和胃肠功能障碍的危重患者的治疗作用。方法:将63例入住ICU的危重症患者分为大黄治疗组和对照组,观察两组患者氧合指数变化、机械通气天数、胃肠功能障碍持续时间及C反应蛋白变化。结果:大黄治疗组氧合指标第3天开始上升(P<0.05),第5天明显改善(P<0.01);大黄治疗组机械通气时间也少于对照组(P<0.05);胃肠功能障碍持续时间,大黄治疗组明显少于对照组(P<0.01);两组C反应蛋白水平第3.5天均有下降,但大黄治疗组C反应蛋白下降幅度均高于对照组(P<0.05);结论:大黄可改善呼吸衰竭患者的氧合指标,缩短患者机械通气天数,能有效改善胃肠功能障碍并减弱炎症反应。

Objective： To observe the curative effect of Radix et Rhizoma Rhei on severe cases complicating respiratory failure and disordered function of stomach intestine. Methods ： 63 cases with MODS in ICU were randomly divided into two groups, which were the treatment group and the control group. Oxygenation index, days of mechanical ventilation, duration of stomach intestine functional disorder and the level of C-reactive protein were ohserved. Result： Oxygenation index in the treatment group was upgraded in the third day （P 〈 0.05 ）, and iraproved obviously in the fifth day （P 〈0.01 ）. The days of mechanical ventilation in the treatment group was less than that in the control group remarkably （ P 〈 0.05 ）. The duration of stomach intestine functional disorder was less than that in the control group （P 〈 0.01 ）. In addition, the level of CRP in the two groups decreased gradually in the third and fifth day, but the treatment group was more obviously than that of the control group （ P 〈 0.05 ）. Conclusions ： Radix et rhizoma rhei can improve oxygenation index of severe cases, decrease the time of mechanical ventilation, amend stomach intestine functional disorder, and alleviate inflammatory reaction.