急性病毒性肝炎中肝炎病毒的多重感染

MULTIPLE HEPATITIS VIRUS INFECTION IN ACUTE HEPATITIS

在243例急性黄疸型肝炎患者中发现肝炎病毒多重感染者77例(31.69％),包括HAV+HBV双重感染65例,HBV+HDV协同感染4例,HAV+HBV+HDV三重感染7例,HBV+CMV重叠感染1例。多重或单一病毒感染组其SB和SGPT升高的水平差异无显著性,但肝炎病毒多重感染与甲或乙型急性肝炎相比,其黄疸消退和SGPT恢复时间均明显延长。

Serological markers of hepatitis virus infection of various etiology were demonstrated concomi-tantly in 77 out of 243 cases (36. 69%)of acute viral hepatitis. Of these 77 cases,56 indicated HAV on top of HBV infection, 9 coinfection of these two viruses as evidenced by coexistence of serum IgM antibodies against HAV and HBcAg, 4HBV/HDV coinfection, 7 triple infection of HAV/HBV/HDV, and 1 superinfection of HBV/CMV. There seemed to be no inhibition of HBV replication in the presence of other hepatitis virus or viruses. In cases with coinfection or superinfection,the duration of hy-perbilirubinemia was significantly longer than those without,and the period of elevated serum transam-inase was also longer than simple acute hspatitis A. Hence, coinfection or superinfection is one of the important factors leading to chronicity of the clinical course.