胺碘酮联用缬沙坦治疗阵发性房颤临床疗效观察

Clinical observation of curative effect of Aminodarone and valsartan combination on curing paroxymlal atrial fibrillation

目的:观察口服胺碘酮联合应用血管紧张素II受体拮抗剂(ARB)缬沙坦在阵发性心房颤动复律后维持窦律的疗效。方法:将145例阵发性房颤分为胺碘酮组(I组,n=72),胺碘酮加缬沙坦组(II组,n=73),疗效观察24个月。结果:治疗6个月后两组左心房内径无显著差异,但12个月后两组有显著差异(p<0.05),窦性心律维持12个月后有显著差异(p<0.05)。结论:胺碘酮与缬沙坦联合治疗阵发性房颤维持,窦性心律的疗效优于单用胺碘酮,并能延缓左心房扩大。

Objective：To evaluate the curative effect of aminodarone, angiotensin receptor block （ARB） and valsartan combination in maintenance of sinus rhythm after cardioversion of paroxymlal atrial fibrillation. Methods 145 paroxymlal atrial fibrillation patients were divided into aminodarone group （group I,n=72） and aminodarone and valsartan combination group （group II,n =73）,and the curative effect for 24 months were evaluated. Results ： After 6 months＇ treatment, the left atrial dimeter （LAD） had no significant difference between the two groups, but after 12 months treatment, there was a significant difference between the two groups（p〈0.05）, and there was a significant difference in maintenance of sinus rhythm between the two groups. Conclusion： Combination of aminodarone and valsartan is more effective in maintenance of sinus rhythm after cardioversion of paroxymlal atrial fibrillation than aminodarone alone, and it can reverse LA enlargement.