一氧化碳中毒迟发性脑病21例临床分析

Clinical analysis of 21 cases delayed encephalopathy caused by Carbon monoxide poisoning

目的:探讨一氧化碳中毒迟发性脑病的发病机制及治疗。方法:回顾性分析21例一氧化碳中毒迟发性脑病的临床资料。结果:21例患者一氧化碳中毒后均以痴呆、震颤麻痹和精神症状为主,MRI提示大脑白质内弥漫性病变,BEAM表现为弥散的慢活动。治疗主要给于激素、高压氧、自由基清除剂治疗。结论:一氧化碳中毒迟发性脑病的治疗愈后与昏迷时间长短、年龄有关。

Objective： To investigate pathogenesis and treatment of delayed encephalopathy caused by the carbon monoxide poisoning. Methods： Retrospective analysis of data collected from the Department of Neurology of our hospital between 2004 and 2007 was made. 21 cases of delayed encephalopathy caused by carbon monoxide poisoning were studied. Results： The main symptoms of 21 cases of carbon monoxide poisoning were dementia, paralysis and mental tremor symptoms. MRI suggested that the diffuse white matter lesions with BEAM performance for the diffusion of slow activity. Treatment methods involve mainly the hormone treatment, high- pressure oxygen and free radical scavengers treatment. Conclusions： The recovery degree of carbon monoxide poisoning delayed encephalopathy is determined by the patients＂ coma time and their age.