头孢呋辛钠与常用输液的配伍稳定性考察

Stability of Cefuroxime Sodium with the Common Used Liquid in the Clinical

目的:建立头孢呋辛钠的含量测定方法,考察头孢呋辛钠与4种常用输液的配伍稳定性。方法:在25℃的室温条件下,模拟临床常用的浓度,对头孢呋辛钠与5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液及5%葡萄糖氯化钠注射液配伍后的含量和pH值变化进行观察研究。结果:头孢呋辛钠与4种注射液配伍后6h内的含量指标和pH值均未有明显变化。结论:头孢呋辛钠与4种输液配伍在6h内稳定。

Objective： Aim To establish a method for the determination of cefuroxime sodium, and research the stability of cefoperazone sodium with the four common used liquid in clinical.Methods： Cefuroxime sodium was extemporaneously compounded with 4 kinds of infusion solutions respectively, and concentration simulated common in clinical. The stability of the mixtures was then characterized in respect of the pH and concentration under room temperature. Result： There was no significant change after matching in the appearance, pH values and content for 6 hours at room temperature. Conclusion： Cefuroxime sodium was compatible with 5% glucose injection, 10%glucose injection, 0.9% sodium chloride injection and ducose and sodium chloride injection in 6h.