4Folkman J. Role of angiogenesis in tumor growth and metastasis,Semin Oncol,2002,29(6 Suppl 16) : 15-18.
5Shichiri M, Hirata Y, Antlangiogenesis signals by endostatin.FASEB J, 2001, 15(6): 1044-1053.
6Huang X, Wong MK, Zhao Q, et al, Soluble recombinant endostatin purified from Escherichia coli: antiangiogenic activity and antitumor effect. Cancer Res, 2001, 61(2) :478-481.
7Kreuger J, Matsumoto T, Vanwildemeersch M, et al. Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function. EMBO J,2002, 21(23) :6303-6311.
8Zatterstrom UK, Felbor U, Fukai N, et al. Collagen XVIII/endostatin structure and functional role in angiogenesis. Cell Struct Funct, 2000, 25(2):97-101.
9Ergun S, Kilic N, Wurmbach JH, et al. Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes. Angiogenesis, 2001, 4(3) : 193-206.
10Karumanchi SA, Jha V, Ramchandran R, et al. Cell surface glypicans are low-affinity endostatin receptors. Mol Cell, 2001, 7(4):811-822.
5Folkman J.Rola of angiogenesis in tumor growth and metastasis[J].Oncol,2002,29(6 Suppl l6):15-18.
6Mass RD,Sarkar S,Holden SN,et al.Clinical benefit from bevacizumab(BV) in responding (R) and non-responding (NR) patients (pts) with metastatic coloreetail cancer (mCRC)[J].Proc Am Soc Clin Oncol,2005,23(16 Suppl):3514.
7O'reilly MS,Beochon T,Shing Y.Et al.Endostatin:an endogenous inhibitor of angiogenesis and tumor growth[J].Cell,1997,88(2):277-285.
8Han Q,Fu Y,Zhou H,et al.Contributions of Zn (Ⅱ)-binding to the struchural stability of endostatin[J].FEBS Lett,2007,581(16):3027-3032.
9Sun Y,Wang J,Liu Y,et al.Results of phase Ⅲ trail of rh-endostatin (YH-16) In advanced non-small cell lung cancer (NSCLC) patients[J].Journal of Clinical Oncology,2005,23(16 Suppl):7138.