52例白塞病回顾性临床分析

A retrospective clinical analysis of 52 cases of Behcet's disease

目的:探讨我国南方地区白塞病(BD)的可能诱因和临床特点。方法:回顾性分析52例白塞病的临床和实验室资料。结果:52例BD中7例合并结核感染,3例合并肝吸虫感染。男女之比为1.4∶1,平均年龄35.4岁,平均病程4.4年。BD可累及多个器官系统,各受累部位的频率依次为:口腔100%,生殖器88.5%,皮肤69.2%,眼40.4%,关节38.5%,呼吸系统5.8%,神经系统5.8%,心脏3.8%,血管1.9%。针刺反应阳性率为65.3%。比较两性在各器官系统受累频率上的差别,发现两性除在生殖器溃疡有显著差异外,余无差异。结论:BD可累及全身多个系统,极易误诊,重要脏器受累预后不良。糖皮质激素或联合应用免疫抑制剂有较好的临床疗效。

Objective：To study the possible inducements and the clinical features of Behcet＇s disease in southern China. Methods： The clinical and laboratory data of 52 BD cases were ana- lyzed retrospectively. Results： 7 cases were accompanied by tuberculosis, 3 cases were found Clonorchis sinensis infection. The ratio of male to female was 1.4 ： 1, mean age was 35.4 years, and average clinical duration was 4.4 years. Many organs and systems were involved, the frequen- cy of affected organs（symptoms） was 100% （oral aphthae）, 88.5% （ genital aphthae ）, 69.2% （skin）, 40. 4% （eye）, 38.5% （joints）, 5.8% （ respiratory system）, 5.8% （ nervous system）, 3.8% （heart） and 1.9% （vessel）. The positive rate was 65.3% for pathergy test. In terms of clinical manifestations, there was no significant difference between male and female except for the incidence of genital aphthae. Conclusion： BD damages multiple systems and is easily misdiag- nosed. The prognosis might be bad if critical organs were involved. Steroid or steroid combine immunosuppressant was effective in treating BD.