^(18)FDG-PET诊断非小细胞肺癌时影响原发灶最大标准化摄取值相关因素的回顾性分析

A retrospective study on correlation between SUV_(max) and influencing clinical factors when ^(18)FDG- PET applied to diagnosis of non-small cell lung cancer

背景与目的:18FDG-PET诊断非小细胞肺癌(NSCLC)时,原发灶最大标准化摄取值(maximal standard uptake value,SUVmax)起关键作用。本研究旨在探讨影响SUVmax的相关临床因素。方法:回顾性分析92例NSCLC患者完全性切除术前所作的18FDG-PET结果,对可能影响原发灶SUVmax的各种临床因素作偏相关分析、单因素方差分析、多重回归与相关分析。结果:偏相关分析提示SUVmax与原发灶大小、病理分期相关(P<0.05),但与年龄、病理分化程度、新辅助化疗疗效无相关性;单因素方差分析揭示腺癌(53例)、鳞癌(24例)、腺鳞癌(4例)、大细胞癌(4例)、鳞腺癌(2例)、巨细胞癌(2例)和细支气管肺泡细胞癌(2例)的平均SUVmax分别为5.18±4.46、7.65±3.57、5.84±3.02、3.35±2.47、6.00±4.59、4.30±1.70和5.85±4.15,组间的平均SUVmax差异无显著性;多重回归与相关分析显示SUVmax仅与原发灶大小相关,但与病理类型、病理分化程度、病理分期、年龄、新辅助化疗无相关性。结论:偏相关分析提示NSCLC原发灶SUVmax与原发灶大小、病理分期相关,单因素方差分析揭示SUVmax在NSCLC各病理类型之间差异无显著性,多重回归与相关分析显示SUVmax仅与原发灶大小相关。

Background and purpose： Maximal standard uptake value （SUVmax of primary lesion plays an important role in diagnosis of non-small cell lung cancer （NSCLC） when ^18FDG-PET is applied, so we investigated the influencing factors that could impact on SUVmax of primary lesion for NSCLC patients detected by ^18FDG-PET before surgery. Methods： 92 NSCLC patients undergoing ^18FDG-PET before complete resection were analyzed retrospectively to detect the correlation between SUVmax, of primary lesion and some influencing clinical factors through partial correlation analysis,One-Way ANOVA and multiple regression and correlation. Results： Partial correlation analysis showed that SUVmax of primary lesion had significantly correlated with the longest diameter of primary lesion and pathological staging（P〈0.05）,.but not with age, pathological differentiation and neoadjuvant chemotherapy（P〉0.05）. One-Way ANOVA revealed that average SUV of primary lesion were 5.18±4.46,7.65±3.57,5.84±3.02,3.35±2.4 7,6.00±4.59,4.30±1.70 and 5.85±4.15 for adenocarcinoma（53 cases）, squamous cell carcinoma（24 cases）, adenosquamous cell carcinoma（4 cases）, large cell carcinoma（4 cases）, sqamous-adenocarcinoma（2 cases）, giant cell carcinooma（2 cases） and bronchioloalveolar cell carcinoma（2 cases） respectively, but no significant difference within groups or between groups（P〉0.05）. Multiple regression and correlation demonstrated that SUVmax of primary lesion had significantly correlated with the longest diameter of primary lesion（P〈0.05）, but not with age, subtype of NSCLC, pathological differentiation, pathological staging and neoadjuvant chemotherapy（P〉0.05）. Conclusion： SUVmax of primary lesion was significantly associated with the longest diameter of primary lesion through both partial correlation analysis and multiple regression and correlation, but with pathological staging only through partial correlation analysis. No significant difference of average SUVmax of primary lesion was found within or between subtypes of NSCLC.