除草剂烟嘧磺隆对大鼠的肝脏毒性初步研究

Preliminary Study on the Toxicity Effects of Herbicide Nicosulfuron on Rats Liver

[目的]探讨除草剂烟嘧磺隆对大鼠的肝脏毒性。[方法]选用SD大鼠120只,随机分成4组,每组设2个平行组(各15只),分别按600、120、50、0 mg/kg,设置高、中、低剂量3个处理组和1个对照组,药物配成乳浊液灌胃。染毒期间每周测定各组小鼠的体重变化情况。染毒结束后,计算脏器系数,测定血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)及碱性磷酸酶(ALP)活力,并检测血清和肝组织MDA含量及肝组织病理变化。[结果]各试验组与对照组相比,小鼠体重、脏器系数、各项肝功指标均无显著差异,高剂量组肝脏有轻微病变。[结论]烟嘧磺隆对大鼠肝脏毒性呈剂量依赖性。对其他脏器的毒性及其慢性毒性作用有待作进一步研究。

[ Objective ] This paper was conducted to study the toxicity of herbicide nieosulfuron to liver function in rats. [ Method ] Four groups of rats （600, 120, 50 and 0 mg body weight per kg） were fed with nieosulfuron with edible oil. Body weight changes of rats in each group were detected weekly during the test. Viscera coefficient were calculated, and ALT, AST and ALP activities were detected as well as the serum and liver MDA contents and the pathological changes of liver tissue. [ Result] Compared with the control group, there were no significant differences among rat body weight, viscera coefficient and liver function index. But the high dosage group had light pathological changes. [ Conclusion] Nieosulfuron showed dose-dependent on the toxicity of rat liver. Its toxicity on other viscera and chronic toxic effect still remained to be further researched.