肝移植术后长期存活患者的远期并发症

Long-term Complications after Liver Transplantation

目的探讨肝移植患者术后远期并发症的发病情况。方法随访我院1998年12月30日-2002年5月28日接受肝移植手术患者,随访至2007年10月仍继续存活的患者共计85例。随访项目包括肝肾功能、血药浓度、血压、血糖、血脂、超声以及必要的其他项目。结果85例长期存活的肝移植患者中远期并发症的发病情况为：移植后糖尿病发生率21.18%（18/85）、移植后高血压10.59%（9/85）、移植后肾功能不全8.24%（7/85）、移植后高脂血症7.06%（6/85）、移植后高尿酸血症7.06%（6/85）、移植后新发肿瘤2.35%（2/85）、移植后新发丙型肝炎7.06%（6/85）、移植后乙型肝炎复发5.56%（4/72）。结论对肝移植术后长期存活的患者重视其远期并发症,以获得受者的长期生存质量。

Objective To investigate the long-term complications after liver transplantation.Methods Totally 85 living patients who received liver transplantation from December 30th 1998 to May 28th 2002 in Tianjin First Central Hospital were followed up till October 2007.Liver and kidney functions,blood drug le-vels,blood pressure,blood sugar,and blood fat were recorded and ultrasound imaging was performed during follow-up.Results At the end of the study,most patients had experienced one or more complications of prolonged immunosuppressant treatment,including posttransplantation diabetes mellitus（21.18%,18/85）,hypertension（10.59%,9/85）,renal impairment（8.24%,7/85）,hyperlipemia（7.06%,6/85）,hyperuricaemia（7.06%,6/85）,denovo malignancy（2.35%,2/85）,new-onset hepatitis C（7.06%,6/85）,recurrent hepatitis B（5.56%,4/72）.Conclusion Recipients of liver transportation often suffers long-term complications,which should be carefully managed to improve their quality of life.