摘要
目的利用16层螺旋CT灌注成像技术研究脑膜瘤瘤周水肿区灌注特点。方法对19例脑膜瘤伴瘤周水肿形成病例行瘤周水肿区同层序列动态增强扫描。利用灌注软件分别计算瘤周水肿区及对侧正常脑白质局部脑血流量(rCBF)、局部脑血容量(rCBV)和对比剂平均通过时间(MTT)。采用t检验对瘤周水肿区和对侧正常脑白质各灌注参数值进行统计学分析。结果瘤周水肿区的rCBF与rCBF较对侧脑白质明显降低(P<0.05),但MTT值在两部位间差别无统计学意义(P>0.05)。结论瘤周水肿区的rCBF值和rCBF值明显降低,水肿本身对微血管的压迫可能是主要因素。
Objective To evaluate the perfusion characteristics of the peritumoral brain edema of intracranial meningiomas using 16-slice spiral CT perfusion imaging. Methods Dynamic contrast-enhanced single-location sequence CT scan was performed in 19 patients with intracranial meningiomas and peritumoral brain edema. The regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and the mean transit time (MTT) were calculated for the peritumoral brain edema and the contralateral white matter and comparatively analyzed. Results The rCBF and rCBV in the peritumoral brain edema were significantly lower than those of the contralateral white matter in patients with meningiomas (rCBF: 14.26±7.44 vs 26.92±15.71 ml/100 g tissue·min, P〈0.05; rCBV: 0.96±0.35 vs 2.47±1.69 ml/100 g tissue, P〈0.05). But the MTT showed no significant difference between the peritumoral brain edema and the contralateral white matter (P〉0.05). Conclusions The rCBF and rCBV are significantly lowered in the peritumoral brain edema in comparison with those of the contralateral white matter. Vascular compression by the edema fluid may have a major effect on the tissue blood flow and blood volume.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第8期1460-1462,共3页
Journal of Southern Medical University
关键词
脑膜瘤
瘤周水肿
体层摄影术
X线计算机
灌注
meningioma
peritumoral brain edema
tomography, X-ray computed
perfusion