Fat-1基因在n-3多不饱和脂肪酸功能研究中的应用

Applications of the fat-1 in n-3 PUFAs Function Research

n-3多不饱和脂肪酸是机体脂肪酸成分之一,维持体内合理的n-3多不饱和脂肪酸比例具有重要的生理意义。但n-3多不饱和脂肪酸在大多数动物体内不能合成,只能从食物中补充。fat-1基因的出现改变了这一现状,它可以将多不饱和脂肪酸从n-6形式转化为n-3形式。综述了n-3多不饱和脂肪酸的功能,并介绍了fat-1基因的功能及转fat-1基因动物在n-3多不饱和脂肪酸功能研究上的应用。

N-3 polyunsaturated fatty acids （PUFAs） is an important component of the fatty acid. It is necessary to maintain the appropriate proportion of n-3 PUFAs physiological. However most animals have to obtain n-3 PUFAs from diet, because they can not synthesize them by themselves. Fat-1 gene, translating into ω- 3 PUFA desaturase, can convert PUFAs from n-6 to n3 form. The main functions of n-3 PUFAs, and the applications and potential of the fat-1 in n-3 PUFAs research are reviewed.