Kimura病、血管淋巴样增生伴嗜酸性粒细胞增多症和肾损伤发生于同一病例

One patient with Kimura's disease and angiolymphoid hyperplasia with eosinophilia also suffers from kidney injury

目的:报道1例少见的同时合并Kimura病和血管淋巴样增生伴嗜酸性粒细胞增多症(ALHE)的患者,并有微小病变性肾小球病导致的肾病综合征;对相关文献进行回顾总结。方法:对患者的活检标本进行组织学、免疫组织化学、免疫荧光以及电镜检查。结果:患者为37岁男性,5年来反复发作皮疹、皮肤结节、颈部淋巴结无痛性肿大和肾病综合征,经病理检查证实,肿大的淋巴结为Kimura病,皮下结节为ALHE,肾病变为微小病变性肾小球病。结论:Kimura病和ALHE可能是同一种疾病的不同病理表现,并可合并肾小球疾病。

Objective： Reporting a rare case with Kimura＇ s disease and angiolymphoid hyperplasia with eosinophilia （ALHE） , who also has nephrotic syndrome resulting from minimal change glomerulopathy. Methods： Histological manifestations, immunohistochemical staining, immunofluorescence staining, and electron microscope were performed. Results： One 37-year-old male patient with recurrent erythra, cutaneous node, painless cervical lymph node enlargement and nephrotic syndrome in 5 years. It＇ s confirmed through biopsies that the subcutaneous node is ALHE, the cervical lymph node is kimura disease, and renal lesion is minimal change glomerulopathy. Conclusion： Kimura disease and ALHE may be different features of the same disease, and may complicate glomerulopathy.