冬夏季节对肾性骨病维持性血透患者肾功能及生化指标的影响

Influence of winter and summer on kidney function and biochemical indexes in patients with renal bone disease and maintaining hemodialysis

目的通过观察冬夏季节肾性骨病患者的肾功能及相应的生化指标的变化来探讨"肾主骨"及"肾应冬"的内涵。方法以慢性肾衰竭尿毒症患者为观察对象,检测冬夏季节他们的肾功能指标、生化指标、血常规等,加以对比。结果肌酐(CREA)、尿素氮(BUN)与甲状旁腺素(PTH)明显高于正常值,呈现冬高夏低的季节性变化趋势。BUN冬夏季节比较有显著性差异,P<0.05。血红蛋白(Hb)冬夏季节均低于正常值。血磷(P)值高于正常值,但冬夏季节比较没有显著性差异,P>0.05。结论肾功能等各项指标的季节性变化,对临床肾与骨相关性疾病因时制宜的预防和治疗有指导作用。

Objective To investigate the connotation of TCM theory of kidney dominating bones and kidney corresponding to winter through the changes of kidney function and biochemical indexes in patients with renal bone disease in winter and summer. Method The patients with chronic renal failure （CRF） and uraemia were taken as the observational objects,and their indexes of kidney function,biochemistry and routine blood tests were detected and compared in winter and summer. Result The levels of creatinine （CREA） and blood urea nitrogen （BUN） and parathormone （PTH） were higher than the normal values significantly in the patients with a seasonal trend of higher in winter and lower in summer. The comparison in BUN levels between winter and summer had a significant difference （P〈0.05）. The level of hemoglobin （Hb） was lower than the normal value in winter and summer. The comparison in phosphate（P） levels between winter and summer had no significant difference （P〉0.05）. Conclusion The seasonal changes of kidney functional indexes is helpful to the prevention and treatment of renal bone disease in clinic based on TCM theory of treatment in accordance with seasons.