受体介导的肿瘤靶向治疗研究进展

Progress on receptor-mediated tumor-targeting therapy of cancer

肿瘤细胞表面过度表达一系列受体,能与特异性的配体结合并诱导细胞内化。以这些受体为作用靶点,使抗肿瘤药物与特异性配体结合即可将药物主动靶向肿瘤细胞。本文就近年来研究较多的受体如唾液酸糖蛋白受体、生长因子受体、低密度酯蛋白受体、转铁蛋白受体、叶酸受体、CD44等进行概述。

A series of receptors expressed in the surface of tumor cells, which are able to mediate internalizing effect by specially connecting with corresponding ligands. These receptors are potential targets for anti-tumor drugs combined with conjugates. So the drug conjugate compounds can be deliveried targetly to tumor cells. This paper summarizes these receptors in recent years, such as sialoglycoprotein receptor, growth factor receptor, low density lipoprotein receptor, transferrin receptor, folate receptor, CD44 and so on.