摘要
目的:研究降压中药鼻腔喷雾剂之挥发油包合工艺和稳定性。方法:采用HP-β-环糊精对降压中药喷雾剂中挥发油进行包合处理,以HP-β-环糊精用量、包合温度、包合时间为因素,进行正交设计,得到最佳的包合条件。结果:最佳的包合条件为:以HP-β-环糊精∶挥发油(7∶1)进行包合;包合温度为30℃;包合时间为1 h。结论:采用HP-β-环糊精包合挥发油能够提高挥发油在制剂中的稳定性。
Objective：To study the volatile oils of antihypertensive nasal spray forming technology and stability. Methods： The volatile oil was clathrated with hydroxypropyl-β-cyclodextrin （HP-β-CD）. The content of HP-β-CD, inclusion temperature and inclusion time were by orthogonal design as evaluating indicators. Result： The optimal inclusion conditions were as follows ： the ratio of hydroxypropyl-β-cyclodextrin and volatile oils is 7： 1, inclusion temperature was 30℃, inclusion time was 1 h. Conclusion. The inclusion of volatile oils with HP-β-CD can enhance drug stability.
出处
《药学与临床研究》
2008年第4期340-342,共3页
Pharmaceutical and Clinical Research
关键词
挥发油
包合
HP-β-环糊精
正交设计
Volatile oils
Inclusion complex
Hydroxypropyl-β-cyclodextrin （HP-β-CD）
Orthogonal design
