围手术期抗菌药物使用抽样分析

Analysis of peri-operation antibiotics administration by random sampling from 2006 to 2007

目的抽样分析某院2006-2007年围手术期病例抗菌药物使用情况,为进一步规范抗菌药物的合理使用提供依据。方法随机抽取2006-2007年手术病历120份,参考相关文献,结合临床实际评价抗菌药物应用是否合理。结果120例手术病例均使用抗菌药物,2年间以术前和术后用药时间不当最为突出。2007年较2006年在药物选择、单次给药剂量、溶媒使用以及术前用药时间等方面有明显改善,Ⅰ、Ⅱ类切口手术术后平均预防用药天数明显缩短。Ⅰ类切口手术中,β-内酰胺类+酶抑制剂在2006年使用最多,二代头孢在2007年使用最多。Ⅱ类切口手术中,2年间以硝基咪唑类、二代头孢使用率最高。Ⅲ类切口手术中,以硝基咪唑类、一代头孢使用率最高。联合用药40例,其中以硝基咪唑类使用率最高,15例不合理。结论该院抗菌药物不合理使用情况已得到一定程度的改善,仍需要加大管理和干预力度,促进抗菌药物的合理使用。

Objective To analyze the peri-operation antibiotics administration by random sampling of a certain hospital from 2006 to 2007, for better specification of rational administration of antibiotics. Methods Antibiotics administration of 120 cases underwent operation from 2006 to 2007 were analyzed randomly, according to the standards. Results All the cases were administrated antibiotics, and the timing of peri-operational administration is strikingly short of correctness among all the aspects of specification. Correctness has improved in other aspects such as drug selection, dosage, dissolve media and pre-operational administration from 2006 to 2007. The period of prevention administration was shortened in Post-operational cases of type Ⅰ, Ⅱ incision. A- mong the cases of type Ⅰ incision, β-Lactam ＋ β-Lactamase inhibitors were chosen in 2006, and the second generation cephalosporins in 2007. Among the type II incision, nitroimidazole,the second generation cephalo- sporins were chosen in 2006 and 2007. Among the type Ⅲ incision, nitroimidazole,the first generation cephalosporins were of the most selection. 15 cases of combinational administration in 40 cases were irrational. Conclusions The correctness of antibiotics administration has fairly improved in the hospital. Still, more measures should be taken to confirm administration to the standards.