梭形细胞肿瘤临床病理与免疫组化特性探讨

Study on the clinnicopathological and immunohistochemistry character of Spindle cell type tumor

目的探讨梭形细胞肿瘤临床病理与免疫组化特性及病理诊断。方法应用免疫组化对34例梭形细胞肿瘤进行回顾性分析。结果梭形细胞肉瘤17例占50％，梭形细胞癌肉瘤10例占26．47％，梭形细胞癌5例占14．70％，其他诊断2例占9、83％。免疫组化31例表达Vim，21例表达CK，14例表达EMA、Actin，8例表达CD117、S-100，7例表达CEA、SM、CD34。CK与Vim同时表达18例，分别表达8例，Vim与CD117同时表达8例，仅CK、EMA、CEA表达3例。结论不同部位的梭形细胞肿瘤，形态学有其病理组织学特征，免疫组化同一梭形细胞肿瘤可有不同或相同抗体表达，不同类型梭形细胞肿瘤可有相同抗体表达，灶性表达非上皮组织来源肿瘤多由分化或转分化而来，结合免疫组化检测可提高病理诊断准确率。

Objective To discuss the spindle-shaped cell tumor clinical pathology and the immunohistochemistry characteristic and the pathological diagnosis. Methods Corried immunohistochemistry on the review analysis to 34 example spindle-shaped cell tumor. Results The splndle-cell sarcoma 17 examples accounted for 50% , the spindle-shaped cell sareocarcinoma 10 examples accounted for 26.47%, the spindle-shaped cell cancer 5 examples accounted for 14. 70%, other diagnose 2 examples to accounted for 9. 83%. Immunohistochemistry 31 examples express the Vim,21 example to express the CK, 14 example to express EMA, the Actin, 8 example express CD117 ,the S-100,7 example express CEA, SM, CD34. CK and Vim simultaneously express 18 exampies,expresses 8 examples separately, Vim and CD117 simultaneously expresses 8 examples, only CK, EMA, CEA express 3 examples. Conclusion The different spot spindle-shaped cell tumor, the morphology has its histopathology characteristic,The Immunohistochemistry identical spindle-shaped cell tumor may have different or the same immune body expression, the different type splndle-shaped cell tumor may have the same immune body expression,the stove expression non-epithelial tissue originates the tumor many comes by the differentiation or the transdifferentiation, the union iimnunity group examination may enhance the pathological diagnosis rate of accuracy.