摘要
目的:使用脑电超慢涨落分析技术(ET),初步探讨2/100Hz经皮穴位电刺激治疗网络成瘾的脑机制。方法:26名被试随机分成对照组和治疗组。对照组12人,接受模拟经皮穴位电刺激;治疗组14人,接受经皮穴位电刺激。比较两组被试12个脑区内γ氨基丁酸(GABA)、谷氨酸(Glu)、乙酰胆碱(Ach)、去甲肾上腺素(NE)的含量。结果:与对照组相比,2/100Hz经皮穴位电刺激治疗1d后,可显著升高治疗组被试F3、C3、F7、T6脑区GABA含量(P<0.05,P<0.01,P<0.001,P<0.05);显著降低F7、T6脑区Glu含量(P<0.01,P<0.05);显著升高T6脑区NE的含量(P<0.05)。治疗5d后,与对照组相比,治疗组被试Glu含量在F7脑区显著降低(P<0.05)。结论:2/100Hz经皮穴位电刺激通过降低脑内Glu含量来发挥对青少年网络成瘾的治疗作用。
Objective：To explore the mechanism of 2/100 Hz transcutaneous electrical nerve stimulation（TENS） effects on adolescents with Internet addiction by applying encephalofluctuograph technology（ET）. Methods： Totally 26 adolescent Internet addicts were randomly assigned into two groups. 12 in the control group were given sham TENS while 14 in the treatment group received TENS. treatment, 2/100 Hz TENS could increase the content of GABA in F3, C3, F7, T6 （ P 〈 0.05, P 〈 0. 01, P 〈0. 001, P 〈0.05）, and NE in T6（P 〈0. 05）, while Glu was significantly decreased in F7, T6 （P 〈0. 01, P 〈0. 05）. The content of the GABA,Ach,NE had no significant difference after 5 days of 2/100 Hz TENS treatment except Glu which was significantly decreased in F7 compared with the control. Conclusion：2/100 Hz TENS＇ effects on adolescents with Internet addiction may due to its ability to decrease the content of Glu in certain brain areas.
出处
《中国药物依赖性杂志》
CAS
CSCD
2008年第4期282-285,共4页
Chinese Journal of Drug Dependence
基金
国家重点基础研究发展计划(973)课题(2003-CB515407)
国家自然基金项目(30170814)
关键词
网络成瘾
经皮穴位电刺激
脑电超慢涨落分析技术
谷氨酸
Internet addiction
transcutaneous electrical nerve stimulation （TENS）
encephalofluctuograph technology （ET）
glutamate （Glu）
