甲型和乙型病毒性肝炎联合疫苗的免疫效果及应用

Immunization Effectiveness and Application of Hepatitis A+B Combined Vaccine

中国是甲型病毒性肝炎(甲肝)、乙型病毒性肝炎(乙肝)高发区,病毒的感染和疾病的流行已对人群健康构成了严重威胁。为减少预防接种的注射次数和漏种机会,提高及时接种率和受种者的依从性,多价联合疫苗已在预防接种中推广应用。甲肝和乙肝联合疫苗(Hepatitis A+B Combined Vaccine,HepA+B)的研制成功和应用,为控制甲肝和乙肝提供了新的工具和有效的途径。国内外临床研究结果表明,HepA+B的安全性、免疫原性、稳定性与单价疫苗相当,能够用于预防甲肝和乙肝。

China is high incidence area in Hepatitis A and Hepatitis B. Infection of hepatitis A and B virus and prevalence of disease remains great threats to peoples＇ health. For decreasing the injection doses, raising timely immunization coverage rate and compliance of the receivers, the muhivalented combined vaccines have been introduced into EPI. The successful manufacturing and using of the combined vaccine against hepatitis A and B provided a new tool and more efficient approach. This kind of vaccine can prevent hepatitis A and B. The results of worldwide or domestic clinical studies indicated that the combined vaccine had the same equivalent safety,immunogenicity,stability as monovalent vaccine.