水相不对称氢化及转移氢化反应研究进展

Progress in Asymmetric Hydrogenation and Transfer Hydrogenation in Aqueous Media

在催化反应中以水代替常用的有机溶剂具有安全、经济、无环境污染等优点,而且在工业应用上,使用两相体系可以在反应完成之后,通过简单的相分离分离出产物和回收有毒的通常也是昂贵的催化剂,因此具有重要意义。本文综述了近年来以水为溶剂的不对称氢化及转移氢化反应的研究进展,重点介绍了前手性底物α-乙酰氨基丙烯酸酯及前手性酮的水相不对称氢化及转移氢化反应,并对其应用前景进行了展望。

Water has many advantages over the usual organic solvents in the catalytic reactions, for its safety, economy and no environmental pollution. From the industrial application point of view,the use of a two-phase system allows an easy separation of the products from the poisonous and usually expensive catalysts by simple phase separation. In this paper, the progress in organometallic-catalyzed asymmetric hydrogenation and transfer hydrogenation in aqueous media is reviewed. The emphasis is laid on the asymmetric hydrogenation and transfer hydrogenation of prochiral substrates such as α- acetamidoacrylic acid esters and β-ketoesters in water. Their application is anticipated.