洗胃对兔口服百草枯急性中毒的治疗作用

Efficacy of gastric lavage in the treatment of oral paraquat-induced acute toxicosis in rabbits

目的:探讨洗胃对兔口服百草枯急性中毒的治疗作用。方法:对随机分组的日本大耳白兔灌胃高剂量或低剂量百草枯,分别在灌胃后不同时间启动洗胃。比较各组兔血百草枯浓度、肺病理改变、兔生存情况。结果:对兔灌胃百草枯10min后启动洗胃能够降低高剂量中毒组的血百草枯浓度,但不能减轻肺损伤及改善预后。对低剂量中毒组,10min后启动洗胃能减轻肺损伤并改善预后;将启动洗胃时间推迟到灌胃百草枯后30min,没有发现洗胃治疗有效。结论:对于较低剂量范围的口服百草枯急性中毒,尽早洗胃可能会改善预后。

Objective To evaluate the efficacy of gastric lavage in the treatment of oral paraquat-induced acute toxicosis in rabbits. Methods Rabbits were randomly divided into two groups , treated with high or low dose paraquat through orogastric tube. Rabbits received gastric lavage at different time after Oral Paraquat-induced acute toxicosis respectively. Rabbit＇s plasma paraquat concentration, lung pathologic changes and rabbits survival condition were compared in different groups. Results Gastric lavage initiating within 10 minutes after Oral Paraquat-induced acute toxicosis could decrease the plasma paraquat concentration of the groups receiving high dose paraquat, but it could not improve the lung condition and prognosis. Gastric lavage initiating within 10 minutes after Oral Paraquat-induced acute toxicosis could improve the lung condition and survival condition of the group receiving low dose paraquat orally. When gastric lavage prolonged to 30 minutes, there was no efficacy. Conclusions For oral low dose paraquat-induced acute toxicosis, gastric lavage initiating timely may improve the survival condition.