尿环氧化酶-2蛋白诊断膀胱移行细胞癌的价值

Clinical evaluation of Cox-2 protein in urine as a marker for diagnosing bladder transitional cell carcinoma

目的:分析比较尿环氧化酶-2(Cox-2)蛋白检测与尿脱落细胞学检查诊断膀胱移行细胞癌的临床价值。方法:选择35例膀胱移行细胞癌和30例作为对照组的前列腺增生症患者,分别行尿Cox-2蛋白和尿脱落细胞学检查,比较2种方法的敏感性、特异性和阳性预测值。结果:尿Cox-2蛋白和尿脱落细胞学的敏感性分别为82.9%和25.7%,差异有显著性(P<0.01),特异性分别为79.1%和100.0%,阳性预测值分别为60.4%和100.0%。结论:尿Cox-2蛋白检测是一种简单、敏感性高、无创的早期诊断膀胱移行细胞癌的方法,适合于膀胱移行细胞癌的诊断与随访。

Objective To evaluate the diagnostic value of Cox-2 protein in urine and urinary cytology in the detection of bladder transitional cell carcinoma. Methods Cox-2 protein and urinary cytology were detected in urine from 35 cases with bladder transitional cell carcinoma and 30 cases with benign prostatic hyperplasia （controls）. The sensitivity, specificity and positive predictive value of two methods were compared. Result The sensitivity of Cox-2 protein （82.9%） in urine was significantly better than urinary cytology （25.7%）. The specificity of Cox-2 protein in urine and urinary cytology was respectively 79.1% and 100,0%, and the positive predictive values was respectively 60.4% and 100.0%. Conclusions Cox-2 protein in urine is a simple, sensitive, non-invasive early diagnositic marker for the detection of bladder transitional cell carcinoma. The detection of Cox-2 protein in urine is suitable for diagnosis and follow-up of patients with bladder transitional cell carcinoma, and its value is higher than urinary cytology.